The Nicotine Discrepancy

[a2dcovert]

Originally Posted by SmokeyJoe

The "hit" sensation from smoking a cigarette is likely either to be due to carbon monoxide (asphyxiation) or the effect of some of the other chemicals in the smoke (some of which are potent monoamine oxidase inhibitors - ie, old school antidepressants) - or both.

Is it possible that this is why some smokers especially myself experience what I describe as a "chemical imbalance" when I quit smoking cigarettes? It is becomming clear to me that the e-cig nicotine delivery is somehow not satisfying all of my needs. I quit smoking 6 months ago and I still get very strong cravings and symptoms of a chemical imbalance, ie mood swings and a high potential for losing my cool.

Kevin

[Scottes]

Originally Posted by Moonflame

I wonder if our bodies just process and get rid of it more effectively without all of the additional stuff in cigs that we're no longer taking in.

Then the "hit" would be different for someone who used organic tobacco, which wouldn't have all of that additional stuff.

Can any ex-organic-analog smoker comment on the difference between those analogs and vaping?

[DVap]

Originally Posted by Scottes

Then the "hit" would be different for someone who used organic tobacco, which wouldn't have all of that additional stuff.

Can any ex-organic-analog smoker comment on the difference between those analogs and vaping?

I don't believe our bodies process nicotine any differently once absorbed due to the tobacco... unless something is modifying the uptake/elimination.

Organic tobacco still has it's 4000 (oft quoted) combustion products, additive laden tobacco would have roughly the same 4000 combustion products plus a number of bonus combustion products.

[TWISTED VICTOR]

[quote=DVap;661943]I don't believe our bodies process nicotine any differently once absorbed due to the tobacco... unless something is modifying the uptake/elimination.

This subject also interests me. I currently vape approx. 42mg/ml. At this level I'm basically vaping the way I smoked, thus, 4-5 drops holds me for 30-45 min, then drip again. So, I've been able to reproduce the same pattern, but, with higher content nic. My question is why so much?

[ShinKun]

I used to smoke American Spirit Light Organics, the orange box, and find that the hit isn't there. Something is missing.

I've been using 20mg ECOpure for the most part. I was down to 10 analogs a day for the last 10 years or so and find that I am vaping to about 6-7 times a day with a couple here and theres for good measure.

A little over a month now and that "something missing" is easier to deal with.

Originally Posted by Scottes

Then the "hit" would be different for someone who used organic tobacco, which wouldn't have all of that additional stuff.

Can any ex-organic-analog smoker comment on the difference between those analogs and vaping?

[Nestran]

The nicotine may very well be getting into the blood just like an analog. the difference is that vaping does not have the chemicals that are used in analogs to speed the blood/brain barrier process.

We are metabolizing more nicotine in the blood than a smoker because it takes longer for it to get from the blood to the brain receptors, which is where we need it to be satisfied.

This is supported by the delayed satisfaction from vaping.

Just my couple pennies, spend them as you wish.

Nestran

[steven.rn]

Originally Posted by Nestran

The nicotine may very well be getting into the blood just like an analog. the difference is that vaping does not have the chemicals that are used in analogs to speed the blood/brain barrier process.

We are metabolizing more nicotine in the blood than a smoker because it takes longer for it to get from the blood to the brain receptors, which is where we need it to be satisfied.

This is supported by the delayed satisfaction from vaping.

Just my couple pennies, spend them as you wish.

Nestran

That might make sense if we were measuring nicotine crossing the blood/brain barrier, but you just measure it with a blood draw from an extremity. It's lower in the entire body's circulation, from what I've gathered, as Kinabaloo was originally pointing out. It's more like it doesn't cross the lung/blood threshold, and get into circulation, or there just isn't as much nicotine in the vapor itself as we might think there would be.

[TropicalBob]

It is becoming clear to me that the e-cig nicotine delivery is somehow not satisfying all of my needs. I quit smoking 6 months ago and I still get very strong cravings and symptoms of a chemical imbalance, ie mood swings and a high potential for losing my cool.

Just to say I am the same. Totally agree with your statements here. I get cravings multiple times a day, while using the e-cigs, snus, dissolvables, Oliver Twist and about three pipes.

Replacing cigarettes after 30 a day for 50 years is not easy. It's more than hitting a specified nicotine blood level.

[Nestran]

Originally Posted by steven.rn

That might make sense if we were measuring nicotine crossing the blood/brain barrier, but you just measure it with a blood draw from an extremity. It's lower in the entire body's circulation, from what I've gathered, as Kinabaloo was originally pointing out. It's more like it doesn't cross the lung/blood threshold, and get into circulation, or there just isn't as much nicotine in the vapor itself as we might think there would be.

Good point. I imagine it is the same situation though. there are chems in analogs to get everything where it needs to go faster. I remember reading something about pH modifiers which would change the rate of lung absorption.

Nestran

[them0nk]

This is an Awesome topic. Where is a doctor with a lab at his disposal when we need one... (year right...)... but i agree with everything i've seen... i DO get those cravings but on the other hand i know if i vap 36mg juice for a little while before bed... i'm WIRED and can't sleep. which doesn't happen to me with 18-24mg juice, i tried like a 5mg mix for before bed and that just didn't work at all, found my self dumping 24mg juice in to get the fix i needed before bed.

But through out the day i've been getting more and more urges now because i'm only on my 2nd week of quitting analogs. The one thing that helps is i work for with my family at a property management company and i'm able to puff all day in my office... so every once in a while i take a puff or two then set it down... i even attend the Smoke Breaks outside with my protege and i'm fine then... it's just weird off moments (SPECIALLY WHEN DRINKING) that i want a cigarette and reach for my 24mg juice and puff puff puff that urge till it's gone lol...