My GP told me, essentially, that nicotine fools your brain (imitates a neurotransmitter and bonds to a receptor) into thinking that there is food in your stomach. And then your brain tells your stomach to start producing acid to digest the food (that isn't actually there). So whether you are smoking, vaping, or chewing nicotine gum the nicotine causes you to have more acid in your stomach than you actually need at any given time. And thus leads to acid-indigestion, GERD, ulcers, etc.
So the thing that has worked for me (when smoking or using an e-cig, and I am not a doctor and I am not your doctor and I don't even play one on TV) is doing something to counteract that--drinking a glass of milk, eating a ginger-nut/ginger-snap, or taking a Nexium or other proton-pump-inhibitor.



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