Vaping is not a complete substitute for tobacco smoking

[Kate]

Originally Posted by Christian

Translated by Google.

I invite you to read this very important release of the National Center for Scientific Research in welcoming the move the courage of the team of Professor Jean-Pol Tassin,



Paris, 23 January 2009
Smoking cessation: how effective substitutes for nicotine?

Nicotine is generally regarded as the main component responsible for the addictive properties of tobacco. Yet, a research team from the CNRS and the College de France directed by Jean Pol Tassin, director of research at Inserm has to prove that nicotine alone is not enough to trigger a state of dependency among smokers. Other compounds in tobacco are needed to reveal the addictive power. This discovery also explains why nicotine substitutes used in smoking cessation are ineffective in the long term.
This work has been published in the advance online edition of the Journal of Neuroscience.

Without being associated with certain components of tobacco, nicotine is not addictive. The main result from the research conducted by Jean Pol Tassin is a further step towards understanding the mechanisms of drug dependence.

Over the past two years (1), this team of researchers has shown that drugs such as cocaine, amphetamines, morphine, alcohol or even lead to a separation (or "decoupling") between two sets of neurons, noradrenergic and serotonergic (2). The first set is to develop external events, the other to control impulses. Dependents feel environmental stimuli in a more intense (including the desire of the product) and lose the ability to control their impulses. Under normal circumstances, these neural circuits to control each other. But the disconnect between the two leads to an imbalance that seems responsible for the process of addiction, the dependent person can no longer restrain his attraction to the product.

It is that nicotine, unlike other drugs, does not decoupling. To try to understand why smoking has, however, a very strong addictive potential, researchers are interested in other compounds. In this new work, scientists demonstrated that the combination of nicotine with other products in tobacco, monoamine oxidase inhibitors (MAOIs), which leads to this decoupling. Specifically, they show that MAOIs can be addictive properties of nicotine because they nullify the action of natural protection that serotonergic neurons have vis-à-vis the nicotine: the serotonin receptor 5-HT1A . The effect of nicotine on the release of serotonin is so intense that happens in fractions of seconds a "feedback control", which then blocked the release of serotonin. This phenomenon of "retro control" is possible only when the 5-HT1A receptors play their protective role. Without this protection, serotonergic neurons are activated by nicotine, they decouple and trigger the process of addiction.

"80% of users of nicotine patches to resume smoking"
In conclusion of this work, the authors explain why the current therapies fail to stop smoking in many cases. Among candidates for quitting smoking, chewing gum and patches are effective at the beginning of treatment, as the effects of persistent MAOI. But after a few weeks of weaning the absence of tobacco (and thus WAMI), permits the return of natural protection. Nicotine alone is not enough as a substitute.

For Jean Pol Tassin "This work could help improve the approaches to treatment of nicotine dependence. They also call into question the effectiveness of current products alternative to tobacco and to understand why, in more than 80% of cases, users of patches and chewing nicotine gum to resume smoking after just a few weeks. A new composition combining nicotine products and blocking the natural protection from 5-HT1A receptors would be effective as an alternative to tobacco. This could be used in a new strategy in the therapy of withdrawal. "



Notes:

1] A new mechanism explaining the drug
2] These neurons synthesize and release of norepinephrine and serotonin. Two neurotransmitters that contribute to the first to regulate attention, emotions, sleep, dreams and learning and the second at various functions such as temperature, sleep, mood, appetite and pain

original article

Important release about nicotine addiction. - *E-Cigtest, the ultimate electronic cigarettes review site and forum* Le site de la cigarette électronique


So it seems that it's not nicotine that some of us miss when we get cravings, it's a combination of chemicals. Raising nicotine intake won't help with that, it'll just raise tolerance or cause illness.

"80% of users of nicotine patches resume smoking" Will this happen with us?

Would it help if we could dose ourselves with harmine?

[robw]

at this point I think the other chemicals we are addicted to are most likely gone. I dont have cravings for them when im vaping so the mental effected of blowing smoke has worked at making you not realize what you were addicted to.

The best thing to do is take this as a mind game the big tobacco is playing with us. If we think we are addicted to the paper in the analog then we will be. It is all in your head.

[TropicalBob]

It is emphatically NOT in my head and even that suggestion boils my blood!

Please read this extremely important research study again. And try to understand it. The reason e-smoking does not satisfy addiction the way cigarette smoking does is because MAOIs are missing. Our liquid's chemists must work on the formula to achieve something that more closely duplicates the pleasure of a tobacco cigarette.

Gotta stop ... gotta stop ... down blood pressure, down ...

[Bellinghamster]

The fact that the other chemicals are gone does not infer that you are no longer addicted to them. That's like telling a 25-year recovering alcoholic that it's OK to partake, since the original alcohol has been gone for 25 years...

Addiction has its mental components, but without a doubt there are very real physical ones as well. This study seems to provide some new insight as to why smoking tobacco is SO addictive [I have friends that kicked heroin and can't stop smoking...]

[RainbowznStarz]

nicotine alone is not enough to trigger a state of dependency among smokers. Other compounds in tobacco are needed to reveal the addictive power. This discovery also explains why nicotine substitutes used in smoking cessation are ineffective in the long term.

scientists demonstrated that the combination of nicotine with other products in tobacco, monoamine oxidase inhibitors (MAOIs), which leads to this decoupling. Specifically, they show that MAOIs can be addictive properties of nicotine because they nullify the action of natural protection that serotonergic neurons have vis-à-vis the nicotine: the serotonin receptor 5-HT1A . The effect of nicotine on the release of serotonin is so intense that happens in fractions of seconds a "feedback control", which then blocked the release of serotonin. This phenomenon of "retro control" is possible only when the 5-HT1A receptors play their protective role. Without this protection, serotonergic neurons are activated by nicotine, they decouple and trigger the process of addiction.

But after a few weeks of weaning the absence of tobacco (and thus WAMI), permits the return of natural protection. Nicotine alone is not enough as a substitute.

Thank you for posting this Kate. It helps explain in my mind WHY I'm still getting cravings/urges for cigarettes.

[ZambucaLu]

All of us here are addicted to some aspect of smoking. Even those who smoke no nic are addicted to at least the ritual of smoking. If not, it would be wiser to just walk away from the whole thing and save themselves a lot of money, wouldn't it?

I'm pretty much beyond the point of trying to figure out what about smoking is addictive. I concentrate now on trying to get as healthy as I can despite the addiction. Maybe someday it will be different.

I sometimes wonder how those who just go cold turkey were ever able to just get over all the addictive aspects of smoking. But they do it....yet it remains a mystery to me. If someone can ever figure out how some are able to do that and others aren't, then I'll really listen.

Lu

[TropicalBob]

That's what it also did for me, Rainbow. It was eye-opening, to say the least. Now we KNOW.

[xpdx]

Originally Posted by TropicalBob

That's what it also did for me, Rainbow. It was eye-opening, to say the least. Now we KNOW.

"And knowing is half the battle!"

(GI JOE REFERENCE)

Sorry I couldn't resist.

Vaping certainly only satisfies part of the tobacco cigarette habit. But like most things in life you have to give up something to get something. I consider e-cigs a middle step to quitting, probably an early step. I'm in no hurry, I have till I die to quit right?

[Satire]

Originally Posted by TropicalBob

Our liquid's chemists must work on the formula to achieve something that more closely duplicates the pleasure of a tobacco cigarette.

Working on it already :P I found a bunch of articles about this type of testing when I was working on the toxicology report. However the only pure MAOIs I have on hand is harmaline and harmine, which are rather safe and temporary (MAO activity returns to normal within 12 hours) inhibitors, but the professional studies say these didn't seem to work on their rats, only the strong (the ones that actually destroy rather than inhibit, taking weeks for the body to re-establish MAO action) MAOIs replicated the self-dosing tendencies of tobacco in their rats. I will see what I can find though. However I will not be publicly posting the results if I succeed (I will PM to anyone interested though), the last thing we need is suppliers to shift efforts from safety issues to "how to make my product more desireable and addictive."

[Silver]

That is strange ! I must've been more addicted to the action then as E-vaping has proved to be a totally sufficient replacement of tobacco smoking for me.

And yet... I have not been able to remove the nic from the equation altogether even though I have tried using only Non nic carts. I now alternate between Low (6mg) and Non, but if I go completely to non, I get more cravings. Perhaps that's in the head as well ?

Cheers,
Silver