Lungs after switching

[Evilfezdog]

my wife is so happy i quit analogs

[Octoma]

Sorry for the :Bump: but

Obama praised the historic legislation, which gives the Food and Drug Administration unprecedented authority to regulate what goes into tobacco products, to make public the ingredients and to prohibit marketing campaigns geared toward children.

Food and Drug Administration has unprecedented authority to regulate the products that go into tobacco products,

HMMM...?? Nicotine is a Product that goes into tobacco products

Soooo do they now have control over all the chemicals used in the production of, or derived from tobacco, and can ban they unapproved use of these substances, Like...... how they control medication

[Octoma]

Hey folks, get your e-cig before they red-tape this industry to the wall.

[Evilfezdog]

that has nothing to do with how your lungs are doing after vapeing
that comment belongs in a different thread

[Octoma]

Sorry just got excited over the issue. I reading that in another tab while I was posting on this issue.

Back on track: Propylene Glycol Monomethyl Ether: A 13-Week Inhalation Toxicity Study in Rats and Rabbits. Landry, T.D., Gushow, T.S. and Yano, B.L. (1983). Fundam. Appl. Toxicol. 3:627–630. Fischer 344 rats (10/sex/exposure concentration) and New Zealand White rabbits (7/sex/exposure concentration) were exposed to 0, 300, 1000, or 3000 ppm (0, 1.09, 3.62, or 10.9 mg/L) of propylene glycol monomethyl ether (PGME) for 6 hr/da, 5 da/wk, for 13 weeks. Minimal effects were observed in animals exposed to 3000 ppm. Indications of a transient central nervous system depression were observed in rats and rabbits exposed to 3000 ppm. There were also small increases (6 to 8%) in mean relative liver weights of 3000 ppm exposed male and female rats relative to controls. Minimal histologic effects were observed in the livers of 3000 ppm exposed female rats. These were suggestive of hepatocellular hypertrophy but were without evidence of degenerative changes. There was an increase in the urinary pH of male rats exposed to 3000 ppm PGME for 4 weeks, but this was not evident after 12 weeks of exposure. There was no indication of histopathological effects in the kidneys of either species, and there were no hematological effects. No treatment-related effects were found in either rats or rabbits exposed to 300 or 1000 ppm.

[Octoma]

Sorry folks copt+paste the wrong one

I think this is useful

Cyclosporine inhalation solution has the potential to improve outcomes following lung transplantation by delivering high concentrations of an immunosuppressant directly to the allograft while minimizing systemic drug exposure and associated toxicity. The objective of these studies was to evaluate the potential toxicity of aerosolized cyclosporine formulated in propylene glycol when given by inhalation route to rats and dogs for 28 days. Sprague-Dawley rats received total inhaled doses of 0 (air), 0 (vehicle, propylene glycol), 7.4, 24.3, and 53.9 mg cyclosporine/kg/day. In a separate study, beagle dogs were exposed to 0, 4.4, 7.7, and 9.7 mg cyclosporine/kg/day. Endpoints used to evaluate potential toxicity of inhaled cyclosporine were clinical observations, body weight, food consumption, respiratory functions, toxicokinetics, and clinical/anatomic pathology. Daily administration of aerosolized cyclosporine did not result in observable accumulation of cyclosporine in blood or lung tissue. Toxicokinetic analysis from the rat study showed that the exposure of cyclosporine was approximately 18 times higher in the lung tissue compared to the blood. Systemic effects were consistent with those known for cyclosporine. There was no unexpected systemic toxicity or clinically limiting local respiratory toxicity associated with inhalation exposure to cyclosporine inhalation solution at exposures up to 2.7 times the maximum human exposure in either rats or dogs. There were no respiratory or systemic effects of high doses of propylene glycol relative to air controls. These preclinical studies demonstrate the safety of aerosolized cyclosporine in propylene glycol and support its continued clinical investigation in patients undergoing allogeneic lung transplantation.

[Niluvani]

lolwut?

wall of text crits you for 139485 points of damage!

[NightElf]

I was about a 1 1/2 - 2pack a day analog smoker -- Yea I had the cough. NOW I maybe smoke 5-10 analogs a day and lowering that with the purchase of a couple more kits. Not only do I wake up to a cough-free morning, but I feel soooo much better. I have energy I didn't think I could have again. Now I do have a very slight *cough* every now and then, but it isn't near as heavy and I have to honestly say there's no gunk anymore. I just can't get around the morning coffee needing a regular cig or after meals.

Thank GOD for this product. I tell everyone -- This has changed my life. And who knows, maybe saved it.

It has made me wonder though, if nicotine isn't the ONLY addictive thing in analogs since I do still get the *crave*.

[NPerez]

I can't say for sure whether my lung capacity is higher, because it's possible that there's some placebo effect, but it feels like it.

What I can say for sure, though, is that the pain/coughing is gone when I breathe in as deeply as possible. I used to be nearly unable to do it. Now I can breathe in all the way.

[caesar]

Smoked for 15 years at least 1ppd. I had troubles using the stairs because I was loosing my breath, now I climb them 2 at once without a problem.
I'm completely analog free for 61 days now and alternating between 0 nic juice and low.