Propylene glycol toxicity

[Bellasin]

Would you mind explaining what " Eosinophil count,reduced reticulocyte count,shift to left of neutrophil" are exactly? Thanks in advance.

Yes please explain this.

[doots]

Originally Posted by crashtestjeep

Im with Doots, I think it say that effects of drying, etc were done after 42 days then the rats were back to normal even tho still exposed? Is that correct? Lotsa BIG words

Lol thats what I got too...

[dirtdocktor]

65 days into an e-cig without so much as a puff of an analog...never felt better!!

[buttercrunch]

2 bunnies for 4 days.....?
hmm.

[dk2]

Originally Posted by idoesmoking

@all : we have conquered the bad habit of smoking cig; and we have to quit e-cig too...its my message to all.

Why quit ecigs I enjoy the pleasures of vaping as much as I did smoking but now I can do it with minimal health risks to myself and bystanders, its calming and rythmic my own little spiritual sanctuary. I'm encouraging everyone to start vaping(that's over eighteen of course)!

[defunkt]

Originally Posted by Bellasin

Would you mind explaining what " Eosinophil count,reduced reticulocyte count,shift to left of neutrophil" are exactly? Thanks in advance.

Yes please explain this.

It would be nice to know what this all means...

[V4Lis4me]

Most of the changes produced in the 90-days of exposure were resolved in a 42-day post-inhalation period. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

Mainly,
I believe it would be in our best interest to know what changes happened in the 90 day exposure.
Not if they resolved themselves in 42 days or not, as we all are in CONSTANT EXPOSURE.... at much higher concentrations!


Where can I find the whole study?
Because, quite honestly, the changes that were invoked in the 90 days are in the real interest of us.

[voltaire]

Originally Posted by idoesmoking

I exposed 2 rabbits to PG vapor (5 minx4 times a dayx 4 days)-two after major meals,two before their defecation.On the 5th day,I stopped it.They were aggressive,a bit constipated too.The control rabbit (one) was exposed to water vapour.

I'm just curious how you knew they were about to poop, and later, how you knew they were constipated? Never mind, maybe I don't want to know!

[V4Lis4me]

Toxicologic evaluation of humectants added to ciga... [Inhal Toxicol. 2002] - PubMed result

this one paints a better picture.....

quoted from above link....

nhal Toxicol. 2002 Nov;14(11):1135-52.Toxicologic evaluation of humectants added to cigarette tobacco: 13-week smoke inhalation study of glycerin and propylene glycol in Fischer 344 rats.

Heck JD, Gaworski CL, Rajendran N, Morrissey RL.
Lorillard Tobacco Co., Greensboro, NC 27420-1688, USA. dheck@lortobco.com
Glycerin (CAS no. 56-81-5) and propylene glycol (CAS no. 57-55-6) are commonly used as humectant ingredients in manufactured cigarettes to control and maintain the moisture content of the cut tobacco filler. The potential of these added humectants to affect the toxicity of cigarette smoke was investigated in a subchronic nose-only smoke inhalation study in rats. Filtered test cigarettes were prepared from an American-style tobacco blend containing either glycerin added at 5.1% w/w tobacco, propylene glycol at 2.2% w/w tobacco, or combinations of these humectants totaling 2.3%, 3.9%, and 7.2% w/w tobacco. Other groups of animals were exposed similarly to the smoke of reference cigarettes without added humectants, or to filtered air (sham control). Smoke exposures were conducted for 1 h/day, 5 days/wk for 13 wk, at target smoke particulate concentrations of 350 mg/m(3). All smoke-exposed groups had equivalent increases in blood carboxyhemoglobin, serum nicotine, and serum cotinine relative to the air controls. Smoke-associated reductions in body weights and occasional increases in heart and lung weights were generally similar among the various exposure conditions at necropsy. Increases in serum alkaline phosphatase and decreases in serum glucose and cholesterol were observed among smoke-exposed females relative to air controls. However, no significant differences in these parameters were evident between the humectant-containing and reference cigarette smoke exposure groups. Assessments of respiration conducted after 3, 6, 9, and 12 wk of smoke exposure indicated an initial smoke-related but not humectant-related decrease in respiratory rate, tidal volume, and minute volume during the first 20 min of each smoke exposure. Respiratory-tract histopathology was consistent across sexes and smoke groups, comprising (1) diffuse and focal alveolar pigmented macrophages and chronic interstitial inflammation in the lung, (2) laryngeal epithelial hyperplasia, squamous metaplasia, and scab formation, and (3) epithelial hyperplasia in the anterior nose. Smoke-related histopathology resolved substantially during a 6-wk postexposure recovery period. Addition of the tested humectants to cigarettes, singly or in combination, had no meaningful effect on the site, occurrence, or severity of respiratory-tract changes or on the measured indices of pulmonary function. It was concluded that the addition of glycerin and propylene glycol to cigarettes does not significantly affect the biological activity of inhaled cigarette smoke in this rat model.

there we go!

[V4Lis4me]

Note they had no effect on pulmonary function.... Meaning the lungs,
the study did not address any other system function..... at least from the text that I was able to find.

Still, great news though.