Propylene glycol toxicity

[Vocalek]

Toxicology. 2010 Jan 15. [Epub ahead of print]
Toxicological considerations on the use of propylene glycol as a humectant in cigarettes.

Gaworski CL, Oldham MJ, Coggins CR.
Altria Client Services, 601 East Jackson Street, Richmond, VA 23261, USA.
Propylene glycol (PG) is a humectant commonly used in cigarettes. Previous toxicological examinations of the effects on the addition of PG to tobacco used mixtures with several other flavoring agents. In the present work, toxicological comparisons were made of experimental cigarettes containing no added PG against otherwise similar cigarettes with three different amounts of PG added to the tobacco. The main toxicological comparison was a sub-chronic inhalation study with mainstream smoke in Sprague-Dawley rats (exposures of 150mg/m(3) of total particulate matter, 6h exposure per day, for 90 consecutive days). The target PG concentrations in the tobacco of the four cigarette types were 0, 4, 7 and 10%. Additional studies with mainstream smoke were bacterial mutagenicity (5 Salmonella strains, both with and without metabolic activation, particulate phase only), cytotoxicity of both particulate and gas/vapor phases (using the neutral red uptake assay), and analytical chemistry (41 analytes). The graded inclusion of PG into experimental cigarettes resulted in increases in the smoke concentrations of propylene oxide, at very low concentrations. Broadly similar responses were seen across the four cigarette types, and the responses were similar to those previously described in the scientific literature. The addition of PG to experimental cigarettes reduced concentrations of some smoke components (e.g. nicotine), but had minimal effects on the biological responses. Most of the changes produced in the 90-days of exposure were resolved in a 42-day post-inhalation period. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

[doots]

So in plain english this means what? lol

[crashtestjeep]

Im with Doots, I think it say that effects of drying, etc were done after 42 days then the rats were back to normal even tho still exposed? Is that correct? Lotsa BIG words

[Jewls]

So in plain english this means what? lol

Me no understand any of that either. I am sure it must be good though?

[Vocalek]

I think that the key take-away message was that adding PG to cigarettes as a humectant "had minimal effects on the biological responses." In other words, it did not appear to be harmful.

I thought it interesting, though, that adding PG reduced concentrations of nicotine. Poor rats probably had to smoke more ciggies to get enough nic.

[idoesmoking]

@Vocalek : Very helpful post.I believed from the day I heard and knew of e-cigs;its an alternative addiction.Like people sniff glue,nail polish remover and hundreds of other stuffs,its like that.e-cig helped me to stop analog cigs- the more dangerous one,I am happy for the fact.I had a WRONG impression,that the companies add something to e-liquid;so,I prepared e-liq in my lab (PG based).I concluded that PG vapor itself has the ability to make one addicted.I had to test it.It would sound inhuman,but I exposed 2 rabbits to PG vapor (5 minx4 times a dayx 4 days)-two after major meals,two before their defecation.On the 5th day,I stopped it.They were aggressive,a bit constipated too.The control rabbit (one) was exposed to water vapour.
The rabbits are in good health now,dont worry :-)
I have no intension to make this report forwarded to any organization,for several reasons.
It is evident to me,I have to quit e-cig too for the benefit of not only my family,but for all who will be benefited by me,directly or indirectly.
Hope it helps some one.
By the way,PG vapor has a bronchodilator action too,(like albuterol (aka Salbutamol))-but the mechanism of action is different),so,asthmatics may find a "relief"-this is from my personal experience-I have asthma.But,I made a peripheral blood film of me,examined under microscope-I have noted the reduced Eosinophil count,reduced reticulocyte count,shift to left of neutrophil-an effect that is produced by high dose prolonged steroid use.
I need more opinion from the super specialists...

[idoesmoking]

@all : we have conquered the bad habit of smoking cig; and we have to quit e-cig too...its my message to all.

[Katmar]

I think that the key take-away message was that adding PG to cigarettes as a humectant "had minimal effects on the biological responses." In other words, it did not appear to be harmful.

I thought it interesting, though, that adding PG reduced concentrations of nicotine. Poor rats probably had to smoke more ciggies to get enough nic.

ROFL...............poor babies, how did they light them without opposible thumbs????

[defunkt]

@Vocalek : Very helpful post.I believed from the day I heard and knew of e-cigs;its an alternative addiction.Like people sniff glue,nail polish remover and hundreds of other stuffs,its like that.e-cig helped me to stop analog cigs- the more dangerous one,I am happy for the fact.I had a WRONG impression,that the companies add something to e-liquid;so,I prepared e-liq in my lab (PG based).I concluded that PG vapor itself has the ability to make one addicted.I had to test it.It would sound inhuman,but I exposed 2 rabbits to PG vapor (5 minx4 times a dayx 4 days)-two after major meals,two before their defecation.On the 5th day,I stopped it.They were aggressive,a bit constipated too.The control rabbit (one) was exposed to water vapour.
The rabbits are in good health now,dont worry :-)
I have no intension to make this report forwarded to any organization,for several reasons.
It is evident to me,I have to quit e-cig too for the benefit of not only my family,but for all who will be benefited by me,directly or indirectly.
Hope it helps some one.
By the way,PG vapor has a bronchodilator action too,(like albuterol (aka Salbutamol))-but the mechanism of action is different),so,asthmatics may find a "relief"-this is from my personal experience-I have asthma.But,I made a peripheral blood film of me,examined under microscope-I have noted the reduced Eosinophil count,reduced reticulocyte count,shift to left of neutrophil-an effect that is produced by high dose prolonged steroid use.
I need more opinion from the super specialists...

Would you mind explaining what " Eosinophil count,reduced reticulocyte count,shift to left of neutrophil" are exactly? Thanks in advance.

[uzzaperez]

dude, you rock. i could use a brain like that. i think I'll sit here and vape and think about it with the one i got.