The FDA approved of a weight loss drug, alli, for OTC availability.
Alli Side Effects lists the side effects of the drugs with their relative percentage of occurrence. From what they tell me, is the drug forces people onto a diet or they crap their pants.

Now, for where the hope comes in, it seems like that is all it takes to get FDA approval. Market e-cigs as a way to get nicotine that makes you not want to smoke cigarettes. If someone ends up soiling themselves, we will have substantial evidence to support our claims.

Don't you just love the FDA?