Next Safety Nicotene Delivery Device

[deewal]

Found this in Other Alternatives. Posted by SJ.

What do you make of it ? How it works it does'nt say but the text and the facts they give could be of use in the argument for an Electronic Nicotene Inhaler.
Some good facts and figures and it does not look like a Cigarette which is what manufacturers should be aiming at.

Next Safety - the biggest breakthrough in NRT?

Nicotine Delivery Device

[ZambucaLu]

This was really interesting Dee. I went on to read more about it but oddly, everything I saw was from mid 2007. I wonder why we haven't heard more about it?

Lu

[katink]

Pity they never remember to heat the spray - that is one real important thing, I think, that keeps people from really finding them a useful substitute.

[deewal]

Pity they never remember to heat the spray - that is one real important thing, I think, that keeps people from really finding them a useful substitute.

That's what i'm trying to find out katink.
If you read down the page to Alternative Nicotine Delivery Systems
it becomes clear that this New Device appears to be something they are working on and are still in the testing period.

Next Safety tobacco addiction expert, Matthew Bars, MS, CTTS, and the Yale University School of Medicine are currently engaged in the development of a research protocol to demonstrate the lung and brain uptake of nicotine from the Next Safety pulmonary drug delivery platform. The Company expects that this research will also demonstrate arterial blood nicotine levels and the pharmacotherapeutic effects of “clean” nicotine delivery via a pulmonary drug platform.
These findings will compare the pharmacodynamics of Next Safety’s pulmonary nicotine delivery and other older and established nicotine replacement medications. This study will also examine the difference between smoked cigarettes and the Next Safety pulmonary device.
“The pulmonary delivery of ‘clean’ nicotine to the human brain has the potential to eliminate tobacco cravings in a similar manner as smoking a cigarette. This would be the gold standard of tobacco addiction treatment.” said Bars. “I have taken the liberty of calling the Next Safety pulmonary nicotine delivery platform the ‘NEXT STEP’ because this next step in the treatment of tobacco addiction has the potential of saving hundreds of millions of lives worldwide,” Bars continued. Besides being a consultant to Next Safety and the pharmaceutical industry, Mr. Bars is also the Director of the Tobacco Cessation Program for the New York City Fire Department. This research should be completed during the first half of 2008.

It is worth a read because they give a very clear,scientific argument for
Tobacco Cessation via Pulmonary methods. That's through the Lungs.
How are they going to deliver Nicotene through the Lungs other than something very similar to Vapour?

[katink]

Yep (and I did read it ) - but vapor is not the same as warm vapor; and up till now, all NRT-devices always use cold vapor. And that puts most people off... Taste is important too of course. But so is temperature... (Not saying this is a bad device 'for an NRT-device' - just saying that is one thing that is missing and that would make it a lot better). Even if cold it might be just as good scientifically... fact remains that people do need to use it to experience any benefits from it. And for that to happen it needs to appeal... to be comfortable if you will. Else it simply won't be used if anything 'more comfortable' is within reach. Like an analog... or like an e-cigarette.

[K0rvet]

Yes, I tried this NRT a few years ago. It is called the Nicotrol Inhaler. Information can be found here:

Nicotrol Inhaler patient advice including side effects

The cartridges were clearly marked and kept in a sealed package, ready for use. It had almost no taste, no odor, no vapor and the throat hit was really harsh. As it is only available by prescription, you are at the mercy of the doctor. If he decides you should be able to quit, he won't renew the refills. That drove me right back to smoking analogs.

The packaging, warnings and all, could really apply to e-cigarettes, though. I don't think there would be as much resistance to e-cigarettes, as in the case of Australia, if the product were advertised with warnings and recommended dosage levels. Advertising it as an NRT with a recommended schedule to quit smoking would really boost acceptance of these products.

IMHO, as long as it keeps us away from tobacco, who cares how long it actually takes us to kick the habit. Should it bother anyone that some might like it enough to keep using it with 0 nic liquids simply for the taste of different flavors? Not likely...

Definitely worth exploring the possibility of repackaging - or adding to the packaging of e-cigarettes with brochures and recommendations on how ot quit smoking, no?

Wonder how long it would take the general public to find out we're just blowing smoke?

[BiscuitSlayer]

Definitely worth exploring the possibility of repackaging - or adding to the packaging of e-cigarettes with brochures and recommendations on how ot quit smoking, no?

No.

K0rvet -

I agree with many of the things you said except for the part I quoted. These can not be repackaged as a cessation device or packaged with info as to how to quit smoking because they haven't been approved by the FDA as a cessation device/method. The first time someone tries to do that, I would imagine that the FDA would ban the use of eliquid, carts, and everything to do with personal inhalers with respect to nicotine uptake.

Ultimately, they should be sold as an alternative to smoking analogs, atleast for now.

If the FDA gets involved in any way, then it is over for us, nationwide. If local or state governments get involved (which is what I would hope for if there is any involvement at all) then it will be handled on a state-by-state basis and fightable by the general public.

On another note:
Personally, I think doctors that don't refill those subscriptions are criminals. How dare they deny something that is keeping someone off of cigarettes, even if the patient is on the inhaler for the rest of their life. The alternative, to me, is much worse.

[deewal]

Yes, I tried this NRT a few years ago. It is called the Nicotrol Inhaler. Information can be found here:

Nicotrol Inhaler patient advice including side effects

Well according to this article it has'nt been on the market yet as he say's

Next Safety tobacco addiction expert, Matthew Bars, MS, CTTS, and the Yale University School of Medicine are currently engaged in the development of a research protocol to demonstrate the lung and brain uptake of nicotine from the Next Safety pulmonary drug delivery platform. The Company expects that this research will also demonstrate arterial blood nicotine levels and the pharmacotherapeutic effects of “clean” nicotine delivery via a pulmonary drug platform.

Then it goes on to say “I have taken the liberty of calling the Next Safety pulmonary nicotine delivery platform the ‘NEXT STEP’ because this next step in the treatment of tobacco addiction has the potential of saving hundreds of millions of lives worldwide,”

So it is going to be called NEXTSTEP and can't have been on the market "a few years ago" as the article and web site are 2007.
Did the NRT you tried look like the pictures in the article ?

[Kate]

I think it's promising that research is taking place on a pulmonary drug delivery device. The intent of the Next device is to tap into the medical market and eventually that might be where personal vapourisers can be developed and researched properly. There seems to be no doubt that it is a useful way to deliver drugs efficiently. If these can be prescribed by a doctor then maybe one day personal vapourisers will be too. What to put in them is another matter, I think there is a lot of scope regarding nicotine, lung disease remedies, cough medicine, expectorant, vitamin E, asthma treatment and I suppose anything that is readily absorbed by the lungs and can be delivered efficiently that way.

EDIT

I've just read this:

"The lungs provide the most direct route of entry for medications into the bloodstream. Once in the bloodstream, medications gain access to all parts of the body including the brain. For psychoactive substances such as nicotine, pulmonary delivery has long been recognized as the most efficient route of delivery. Pulmonary drug delivery has been limited to this point, due to an absence of technology that allows this route to be utilized.

"Seventy years ago, methods to allow intravenous drug delivery were developed. Intravenous delivery is the channeling of liquid substances directly into a vein. Today, intravenous therapy is $100+ billion global market."

When we can say this with formal medical approval we will have made it:

"Nicotine Replacement

"In typical use, none of the current nicotine replacement therapy formulations achieves nicotine levels like those seen during typical smoking, leading to the idea that higher doses may be needed. The PDP delivers nicotine with higher efficacy than a cigarette. Importantly the PDP delivers nicotine safely, unlike cigarettes."

http://www.nextsafety.com/pulmonary-drug-delivery/

[deewal]

When we can say this with formal medical approval we will have made it:

"Nicotine Replacement

"In typical use, none of the current nicotine replacement therapy formulations achieves nicotine levels like those seen during typical smoking, leading to the idea that higher doses may be needed. The PDP delivers nicotine with higher efficacy than a cigarette. Importantly the PDP delivers nicotine safely, unlike cigarettes."

Pulmonary Drug Delivery

Exactly Kate. That's why i thought it was worth a read because of the way they are scientificly wording and describing the reasons why Alternative methods should be considered and the fact that they are an already established Company which are legally trading.
The Figures they quote of the number of people worldwide that are still smoking Cigarettes is also useful. (Though if they all stopped and did'nt die of Smoking related Diseases i don't know how the hell the Planet could feed them. )
Trying to fight these Anti-Nicotene of any sort Fanatics is like wading through treacle. The biggest problem with them is that they are making their living out of it.