New Vaccine for Nicotine Addiction

[rothenbj]

Now, now the ANTZ are our friends. Well, they would be if E Cigs were brought to market by BP.

[Petrodus]

Now, now the ANTZ are our friends. Well, they would be if E Cigs were brought to market by BP.

In the military ... We had something called a Blanket Party
I would be all for having such a party with the ANTZ as the guests of honor.

[CES]

so...there are a couple of primary issues with any vaccine of this type.

the first is that you can inject someone with the vaccine, and they'll make a few antibodies against nicotine, but antibody production really only gears up when you're exposed to the substance. So it's not likely to be very effective against people who aren't exposed to nicotine. If it were safe, the possibility exists that the vaccine would block any pleasurable effects from nicotine if someone was experimenting with smoking. It wouldn't do a darn thing for the carbon monoxide high.

However, if used by someone who has nicotine cravings, the vaccine would be one of the most miserable methods to quit that i could think of. If people who use nicotine/smoke try the vaccine, it will block the effect of nicotine, but not the cravings, and a subset of people are likely to try to use more and more nicotine to assuage the cravings. Since antibody production is also slower than nicotine intake, individuals will have some success in reducing the cravings just by taking in more nicotine - or smoking - even more. Not the most healthy option. There is/was a similar vaccine that was made against a substance that used to be in coca-cola, and it has not been very successful or widely used AFAIK, possibly because some people just used a whole bunch more of the substance.


The other more problematic part is what happens to the nicotine that is bound by the antibodies, and do the antibodies bind only nicotine? Studies on the vaccine have been ongoing for more than a couple of years. A couple of early rat studies indicated that the antibody-bound nicotine was sequestered in some tissues of the body, and none of the early studies that i looked at included data that showed that antibodies bound only nicotine and nothing else.

ETA, here's a discussion about it from a couple of years ago http://www.e-cigarette-forum.com/for...ml#post1085061

[TennDave]

so...there are a couple of primary issues with any vaccine of this type.

the first is that you can inject someone with the vaccine, and they'll make a few antibodies against nicotine, but antibody production really only gears up when you're exposed to the substance. So it's not likely to be very effective against people who aren't exposed to nicotine. If it were safe, the possibility exists that the vaccine would block any pleasurable effects from nicotine if someone was experimenting with smoking. It wouldn't do a darn thing for the carbon monoxide high.

I guess you would no longer have the pleasurable effects from eating eggplant, peppers and tomatoes either then. ~sigh~

[supergerbil]

This sounds a bit sketchy.

I think I will stick to my nic addition rather than having my liver genetically modified thank you very much.

[Khalifa247]

I only vaccinate my dog for rabies.... because she travels with me... and because they usually cause problems in dogs I like to fore-go the ones she doesn't need. Ill pass... that is just me though.

[Petrodus]

Reminds me of the last time my elderly father was in the hospital.
Since I have power of attorney ... The nurse asked if he had a
a recent flu shot. I replied NO ... No one in our family wants to
run the risks. She said ... "I wouldn't have taken the shot either
but the hospital requires that we all employees take the shot"

[Cool_Breeze]

so...there are a couple of primary issues with any vaccine of this type.

the first is that you can inject someone with the vaccine, and they'll make a few antibodies against nicotine, but antibody production really only gears up when you're exposed to the substance. So it's not likely to be very effective against people who aren't exposed to nicotine. If it were safe, the possibility exists that the vaccine would block any pleasurable effects from nicotine if someone was experimenting with smoking. It wouldn't do a darn thing for the carbon monoxide high.

However, if used by someone who has nicotine cravings, the vaccine would be one of the most miserable methods to quit that i could think of. If people who use nicotine/smoke try the vaccine, it will block the effect of nicotine, but not the cravings, and a subset of people are likely to try to use more and more nicotine to assuage the cravings. Since antibody production is also slower than nicotine intake, individuals will have some success in reducing the cravings just by taking in more nicotine - or smoking - even more. Not the most healthy option. There is/was a similar vaccine that was made against a substance that used to be in coca-cola, and it has not been very successful or widely used AFAIK, possibly because some people just used a whole bunch more of the substance.


The other more problematic part is what happens to the nicotine that is bound by the antibodies, and do the antibodies bind only nicotine? Studies on the vaccine have been ongoing for more than a couple of years. A couple of early rat studies indicated that the antibody-bound nicotine was sequestered in some tissues of the body, and none of the early studies that i looked at included data that showed that antibodies bound only nicotine and nothing else.

ETA, here's a discussion about it from a couple of years ago http://www.e-cigarette-forum.com/for...ml#post1085061

Thank you for the analysis of the scientific matter at hand.

[Los Marauder]

CES- Thanks for the info. Took me 2-1/2 hours to realy understand it.(I hope) Interesting that at stage 3 the subjects that did not stick to substained abstinence, were only smoking about 10 cigs a day rather than the 20 before the study. Don't realy get this, because the vacine is supposed to block the nic. Could this be because of lower micrograms of vacine to some subjects? I figured they would be smoking like twice as many to get some nic past the vaccine and to the receptors. Interesting also that placebo had 6% success at 12 months. Not as high as the Nic Vax 16% but a damn sight cheeper too. Also interesting that they give counceling at target susation point.

With a projected 2.1 billion in sales of nicotine vacines in 2018 there is a lot of money in that 10% offset from placebos.

[CES]

hmmm. The lack of abstinence at stage 3 could have been due to not producing enough antibodies...or it could be that the nicotine effects are completely blocked, but that smoking isn't just about the nicotine. It could be the other chemicals in smoke, or just about the hand to mouth (as so many of us know through our own experiences) .

The success rate with placebo vaccine is just about that of FDA approved NRTs, so in early clinical trials the real vaccine was a bit better than the patch or gum. wonder if those projected billions in sales include the booster shots for the other 84% who the vaccine didn't quite work for.....