The Good, the Bad, and the Ugly
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Thread: The Good, the Bad, and the Ugly

  1. #1
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    Default The Good, the Bad, and the Ugly

    UTSA scholars to study health effects of electronic cigarettes

    The Good:

    UTSA scholars to study health effects of electronic cigarettes

    Scholars William Cooke and Donovan Fogt have received $30,000 in seed funding from UTSA to find out. The UTSA kinesiologists will team up with Assistant Professor Caroline Rickards at the University of North Texas Health Science Center to gather baseline data about the effects of e-cigarettes on the body's basic physiological health.

    For six years, e-cigarettes have been aggressively marketed as an alternative for smokers who want to decrease their risk of the serious health problems associated with conventional cigarette smoking. Instead of inhaling a cigarette's nicotine and carbon monoxide, e-cigarette users inhale vaporized pure nicotine. But, very little research has been done about the effects of inhaling vaporized nicotine.

    Over the next year, the researchers will study the effects that inhaling vaporized nicotine has on a person's heart rate, blood pressure, resting metabolic rate, physical work capacity and brain blood flow.
    UTSA students pursing kinesiology and health-related careers will conduct research alongside the scholars, giving them the opportunity to learn quantitative research methods in preparation for their careers in academia and health-related professions.
    The Bad:

    The scholars will work under the hypothesis that vaporized nicotine stimulates the human nervous system in ways that could seriously impact daily living. They believe that the inhalation of vaporized nicotine has the potential to increase a person's resting metabolism, making exercise problematic. They also believe it prevents the cardiovascular system from properly regulating arterial pressure and decreases the brain's ability to regulate blood flow.


    "E-cigarettes are perceived as safer than actual smoking, and some people even perceive them to be an attractive weight-loss tool," said Fogt. "This study aims to quantify the metabolic consequences of inhaling vaporized nicotine."
    Cooke added, "This study is an important first step to understanding the physiological complications and public health concerns surrounding the use of e-cigarettes. It will also give us a better understanding of the health effects of pure nicotine without the harmful poisons found in tobacco products on the autonomic nervous system."


    If this study confirms the scholars' hypotheses, additional research will be needed to further understand the immediate effects of vaporized nicotine, the impact of dosage and age on an e-cigarette user's health and the long-term effects of e-cigarettes."
    The Ugly:

    I understand the basics of structuring a research project. Usually a negative hypothesis is proposed: "X does not have the effect of Y." Then when little to no evidence is found to support the negative hypothesis, the study provides evidence that "X does have the effect of Y."

    However, even though the wording of the hypothesis displays a negative attitude toward e-cigarettes, it is not formulated as a negative hypothesis statement. "The scholars will test the hypothesis that inhaling vaporized nicotine does not stimulate the human nervous system in ways that could seriously impact daily living."

    Also, given the fact that e-cigarettes were never intended to be marketed to the entire population, any testing of this sort should compare the physiological effects of Method A of obtaining nicotine (smoking) to Method B (vaping) to provide the public with a complete picture of the effects of switching from smoking to vaping.

    So the full hypothesis to be tested would be "inhaling vaporized nicotine has a worse impact on the human nervous system than inhaling smoke."
    wv2win, YKruss, Killjoy1 and 5 others like this.


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    ECF Guru ECF Veteran wv2win's Avatar
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    When a study is specifically set-up to prove a negative instead of simply report the findings against a control group, which should be smokers, it doesn't sound like it will be objective.
    Last edited by wv2win; 07-15-2013 at 03:10 AM.

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    But, very little research has been done about the effects of inhaling vaporized nicotine.
    I beg to differ. Where are all those studies that would have been required from the pharmaceuticals before they started marketing NRTs in inhaler form?

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    Quote Originally Posted by retired1 View Post
    I beg to differ. Where are all those studies that would have been required from the pharmaceuticals before they started marketing NRTs in inhaler form?
    Excellent point.

    Here is an animal study:

    Life Sci. 1996;58(16):1339-46.
    Long-term effects of inhaled nicotine.
    Waldum HL, Nilsen OG, Nilsen T, RÝrvik H, Syversen V, Sanvik AK, Haugen OA, Torp SH, Brenna E.
    Source

    Department of Medicine, University Hospital, Tronheim, Norway.
    Abstract

    Tobacco smoking has been reported to be associated with increased risk of cardiovascular disease and cancer, particularly of the lungs. In spite of extensive research on the health effects of tobacco smoking, the substances in tobacco smoke exerting these negative health effects are not completely known. Nicotine is the substance giving the subjective pleasure of smoking as well as inducing addiction. For the first time we report the effect on the rat of long-term (two years) inhalation of nicotine. The rats breathed in a chamber with nicotine at a concentration giving twice the plasma concentration found in heavy smokers. Nicotine was given for 20 h a day, five days a week during a two-year period. We could not find any increase in mortality, in atherosclerosis or frequency of tumors in these rats compared with controls. Particularly, there was no microscopic or macroscopic lung tumors nor any increase in pulmonary neuroendocrine cells. Throughout the study, however, the body weight of the nicotine exposed rats was reduced as compared with controls. In conclusion, our study does not indicate any harmful effect of nicotine when given in its pure form by inhalation.
    http://www.ncbi.nlm.nih.gov/pubmed/8614291
    Last edited by Vocalek; 07-14-2013 at 09:43 PM.
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    Irreverant reaction to this:
    The scholars will work under the hypothesis that vaporized nicotine stimulates the human nervous system in ways that could seriously impact daily living.
    They could, of course, just ask the hundreds of thousands of vapers whether vaporized nicotine has impacted their daily lives...

    But seriously. Nothing in the description of this research project indicates there will be a control group (either smokers, or non-nicotine users), so can I conclude the study will be straight research on the one target population? If so, it will be interesting, but lacking comparison to smoking, pretty much irrelevant as far as I'm concerned. Also, will the test subjects be former smokers, and if so, might not that give different results than if the TSs are never smokers?

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    I find it funny that they want to prove vaping to hamper physical activity. When I gave up analogs 18 months ago I also changed my life in general I have lost 125 pounds and this last Monday went on a 50 mile bicycle ride. I would say that I wouldn't have been able to accomplish this were I still smoking.

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    Thirty thousand isn't much for a study I would think and If I knew any study on anything had this small amount in their check book, I wouldnt even bother to read or concern myself with it. Maybe I am showing my ignorance here, I don't know. How about we band together and take donations to conduct a study of our own and give the money to who ever is the most revered/respected research lab/college that the powers that be know of or would heed or believe in their findings ?

    I would like to think we could certainly come up with more than 30K towards the study.

    If some one starts a fund we would trust, I will pledge 10.00. Thats not much, but if we all pitched in what we could..... just sayin.... or maybe that's easier said than done.
    Last edited by Thunderball; 07-14-2013 at 10:10 PM.
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    CASAA had or has a research fund for a specific project, then I believe they were raising additional funds for other productive endeavors. I believe it went rather well, Though I don't speak for CASAA so I will let them explain. I think donating period is a must at any dollar amount. I just wish there was a way to gain mass exposure for them. I would love to see more awareness at B&M's and e-commerce sites!
    wv2win and Thunderball like this.
    VAPE PROUD!

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    Sarcasm Alert
    Guess we just have to prove the water quenches thirst thing

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    Quote Originally Posted by 2coils View Post
    I just wish there was a way to gain mass exposure for them. I would love to see more awareness at B&M's and e-commerce sites!
    I was thinking the same thing... A donation tin on every B&M counter. How to do that ? Also, how to explain that to new Vapeing folk.
    Keep Calm and Vape On !


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