Nicotine absorbtion from vaping research

[Sun Vaporer]

So just how much dopamine or other MAOI's are we thinking are added
to cigarette tobacco, presumably this is a deliberate part of the formulation?

Is this really the most likely cause of ciggies being more 'satisfying',
or only a small part of the complex equation?

Exo--Good to see you my friend---you have been missed by so many here!!!!!

Sun

[exogenesis]

Hi Sun Vaporer,
thanks for the (probably undeserved) ego boost,
suspect I wasn't missed that much

Couldn't resist the '75mg liquid' thread, having had a shot at vaping different types of the 'strong stuff'.

[TheLizinator]

From what I can gather online, MAOIs are simply a byproduct of tobacco smoking:

Human monoamine oxidase is inhibited by tobacco smoke: beta-carboline alkaloids act as potent and reversible inhibitors
by
Herraiz T, Chaparro C.
Spanish Council for Scientific Research, CSIC,
Instituto de Fermentaciones Industriales,
Juan de la Cierva, 3,
28006, Madrid, Spain.
Biochem Biophys Res Commun. 2005 Jan 14;326(2):378-86

ABSTRACT

Monoamine oxidase (MAO) is a mitochondrial outer-membrane flavoenzyme involved in brain and peripheral oxidative catabolism of neurotransmitters and xenobiotic amines, including neurotoxic amines, and a well-known target for antidepressant and neuroprotective drugs. Recently, positron emission tomography imaging has shown that smokers have a much lower activity of peripheral and brain MAO-A (30%) and -B (40%) isozymes compared to non-smokers. This MAO inhibition results from a pharmacological effect of smoke, but little is known about its mechanism. Working with mainstream smoke collected from commercial cigarettes we confirmed that cigarette smoke is a potent inhibitor of human MAO-A and -B isozymes. MAO inhibition was partly reversible, competitive for MAO-A, and a mixed-type inhibition for MAO-B. Two beta-carboline alkaloids, norharman (beta-carboline) and harman (1-methyl-beta-carboline), were identified by GC-MS, quantified, and isolated from the mainstream smoke by solid phase extraction and HPLC. Kinetics analysis revealed that beta-carbolines from cigarette smoke were competitive, reversible, and potent inhibitors of MAO enzymes. Norharman was an inhibitor of MAO-A (K(i)=1.2+/-0.18muM) and MAO-B (K(i)=1.12+/-0.19muM), and harman of MAO-A (K(i)=55.54+/-5.3nM). beta-Carboline alkaloids are psychopharmacologically active compounds that may occur endogenously in human tissues, including the brain. These results suggest that beta-carboline alkaloids from cigarette smoke acting as potent reversible inhibitors of MAO enzymes may contribute to the MAO-reduced activity produced by tobacco smoke in smokers. The presence of MAO inhibitors in smoke like beta-carbolines and others may help us to understand some of the purported neuropharmacological effects associated with smoking
wtf...swims never heard this before.

[fellcolor]

I suspect it depends a great deal on the device and how the device is used. Like several others here, the 510 with 24mg fluid often gives me a very noticeable buzz that I hadn't seen for years with the rather high nic. analogs I'd been smoking. The 4081 was a nice vape, but I kept hanging on to the analogs while I was using it, and it just wasn't quite connecting.

[kinabaloo]

I enjoy your posts Bob

I'd imagine this has been covered before, but wouldn't the e-cig in use have a direct effect on the amount of nicotine? In an analog most of the nicotine is destroyed in the burning process. So in a hotter atomizer (mods, 510s, etc..) is it possible nicotine is being destroyed?

This has crossed my mind often in the last month or so, but I always forget to ask when I'm on the forums. A friend of mine switched from the 510 to the 901 and claimed he can't vape as much, and it reminded me to ask!

In a recent post I explained why in fact analogs may give up their nicotine with less loss; the nic vaporises as the fire slowly approaches; it doesn't wait to burn up in the flame! In contrast, in e-cigs some nic may get burnt before it has a chance to vaporise and becomes part of the deposit (it's only my theory, but seems perfectly feasible).

Will look into the inhibitor - dopamine angle as I get time ...

[Throat hit]

Not much to add apart from this is the best post I have seen yet on nicotine and the rate of absorbsion and why it lacks the buzz of a cigarette. I only use weak juice at about 5mg/ml any more and I need a sit down and get red in the face. The first day of vaping I went shopping and was on a great buzz with a huge sense of inner calm. I know I am getting a good dose of nicotine just not the other side effects of a ciggy. As the buzz is the most addictive part I for one miss it but accept it as a good thing breaking down any addiction is part of the road of understanding it and overcoming it. I am lucky as can start and stop smoking at will with only mild cravings. I know from reading this forum and living with a very heavy smoker I am very lucky. Am I to think as I can start and stop at will and I only need a small amount of nicotine to get buy I ony have a small number of receptors. Great food for thought thankyou