Nicotine absorbtion from vaping research

[Kate]

'... fast-acting free-base form given by cigs ...' That might be the answer, maybe it takes more than five minutes to get into the bloodstream.

I don't know but those results do not reflect my experience at all. I never got buzzy with roll ups but anything over 11mg eliquid makes me buzzy.

I got terrible palpitations with a couple of minutes of 36 once.

[Kate]

I was asked to issue a warning by Dr Eissenberg about nicotine. It's what we already know about lethal doses and being careful but it's from a professional to us and should be posted:

"... *please* be careful handling the liquid that goes into these cartridges, and also ask your colleagues to do the same. The lethal dose of nicotine for an adult human is 40-60 milligrams and, if we are to believe the manufacturers, 2-3 cartridges contain about that dose, and the bottles of liquid that can be purchased over the internet contain much higher doses. Nicotine can be absorbed through the skin and acute nicotine poisoning is a very painful (and totally unnecessary) way to die. Keep the cartridges away from children and pets, and don't handle the liquid or use gloves if you must."

[katink]

My own experience, and I have heard it from others also: when you first start vaping, what really stands out is the feel of the nicotine: it is very clean nicotine. I think this might have to do why, even if plasma-levels might be low, it performs better somehow.
Just my feeling, can't corroborate with evidence but it has been my feeling on the nicotine. Perhaps, because of this, less nicotine 'does' more...
(Plus of course this is a good explanation why we vape a lot more then we smoked - simply takes more vaping to get what we want/need)

Lets not forget that the e-cig WORKS for oh so many... this means it is enough for all those that manage to convert to e-cigs. Lets not translate this into 'oh, now it suddenly doesn't show to be working, lets take more'. In fact, that this works for so many while showing less in the blood, should make us happy. This opens much better perspectives to get this approved through which-ever way (who knows, maybe even the homeopathic route would offer a better chance knowing this?) Lets not 'waste it away'...

[Xeon1979]

Tropical bob has been saying this for a long time now. it looks like he was correct. I would take the word of a guy who is severely hooked on nicotine.

People here are saying pure nicotine. what if it is the opposite. what if the nicotine in e-cigs is not pure. or its another chemical or reaction all together that are giving people the nicotine overdose symptoms.

[Tugger]

If you want to see if the overdose symptoms are from something else, just have someone who gets these symptoms vape the amount of 0nic juice that would normally give those symptoms. I'm a little dubious myself.

And the fact that most of us vape all day totally lines up with the research, we're just trying to normalize the blood nicotine concentration we're used to. I always thought it was strange that unless I'm drinking, I really don't want to smoke for at least an hour or two, but I pretty much want to vape all day long. It never made any sense.

[LuckySevens4U]

Okay my brain isn't working here......I'm tired....is this news good or bad? Is it saying that we have to vape a TON more to get the amount of nic out of a ciggy?

[Tugger]

Lucky, yes, by about 10 times as much it looks like, which is scary for a number of reasons, the most obvious of which is that lots of people report symptoms of nicotine overdose vaping less than twice as much nicotine as we're used to.

Lotta questions here.

[Drewsworld]

I think the thing that we are overlooking here is that Phillip Morris and friends have spent decades figuring out how to tweek their nicotine for maximum absorption into our lungs, which is why they are paying billions of dollars in fines for the next decade or so...They got CAUGHT ADDING POISINS INTO THEIR PRODUCTS!!!! And I still buy it..You think its addictive?...They have 4000 chemicals added to their tobacco products to make them MARKETABLE...Well I guess I got carried awayon this one, but in 10 years or so when we figure out how to make our juice more palatable we will have to vape much less.

[Tugger]

Not buying it. I've smoked handrolled cigarettes with "no additive" tobacco. They're much more satisfying than PVs (not that PVs are so bad, they're still pretty great.)

Another thing, has anyone noticed that Hookah's are not satisfying like analogs, I never understodd that either, while we're here.

[lachesis]

but didn't that NZ study did say 99% gets absorbed... Maybe I'm remembering it wrong. Very interesting outcome, indeed - and yes, after reading this, I just took my 18mg (highest I have) and finished the entire cart, little buzzed.