Society for Research on Nicotine and Tobacco conference

[silverfox]

if you take a look at the chart in Kate's 1st post it starts to make sense when you look at the time involved...the testing stated the results after 5 mins, which shows a huge spike in concentration in that 5 min window, but, after 30 mins, or 50 mins, all the delivery systems are very similar....

[ISAWHIM]

By the research...
From what I have found, in relation to the research results...

With "Certified Ruyan liquid", which uses synthetic nicotine, which does not qualify for "Natural Nicotine", and can not be measured the same way... (The test does not indicate that they tested the Ruyan product for levels of nicotine, they only state the "Marked", label, and do not mention if this was pre-synthetic production, or the new synthetic production.) There are several versions of nicotine. It is not a simple compound like water or carbon monoxide.

By the statistics/measurements, the "Certified Ruyan liquid", appears within range. However, you can OD on the patch, which shows as the lowest value on the chart.

You also have to remember, "Ruyan" is not the only person selling liquid as "Ruyan". There are many counterfeit sellers, who are not using "Ruyan's certified synthetic nicotine", they are selling nicotine extracts, and commercial/industrial poison/salts as nicotine. (Mostly the same thing, but they do not have the same reactive test results.)

"Plasma in nicotine", is a poor test. It shows no relation from one device to another, and does not indicate the bodies reaction to nicotine. It does indicate the volumes absorbed, and decaying in time, as the body reacts to the specific "Type" of nicotine and delivery "Dose".

Cigarettes, delivered as a blast, directly into the blood, through the lungs, with carrier chemicals in the mixture, rises fast, and peaks where the body has "Limited", due to chemical resistance with anti-bodies or natural liver filtration, or saturation due to osmosis through the lung-walls.

On the contrast, the patch, delivering a long-delay as it trickles through the skin, slides under the reactive radar in your body, delivering a constant feed which usually results in a compounding escalating effect. This can result in an unexpected heart-attack, where the user may not have needed nicotine, but it is uncontrollably being delivered as it passes through the glands and releases from the water in the fatty cells. (Removal of the patch will result in hours of nicotine delivery after the removal.)

The vaporizer was not in that test, only the charts/values related to inhalers, which are liquid volumes, similar to a patch, and not a true "Mist", or evaporated mist, as a vaporizer delivers. (Droplet size of an inhaler is large, and designed to deliver liquid to the nasal passage or throat, by majority. While a vaporizer delivers smaller droplets, intended for the lungs if inhaled, or the mouth if taken only orally.)

The missing data from that study, is the actual level of consumed nicotine in relation to the bodies output reaction. Blood-pressure, heart-speed, respiratory gaseous exchange, and self regulation habit, as opposed to a fixed-delivered dose, is what determines risk.

If self-regulated gratification is reached before high levels of risk are reached, compared to something like a cigarette, or an unregulated patch, this would determine the potential level of risk of the user. (Patches are unregulated, as they can not be effectively metered. The function is based off absorption and level of perspiration, both are not a standard and uncontrollable by the user.)

Also note...

Those values all start at 0mg... That indicates the tests were done on a non-user, without resistance, with potential perfect health, and with a potential inability to fight-off or normalize the bombardment of foreign matter being delivered into the body.

The chart also stops after one minute, and you can clearly see that all except the patch, are tapering away from high-concentration to low-concentration. The patch is on a steady incline upwards on that chart, even after one hour.

What does it show???

Cigarette, Full peak absorption after ~7 minutes.
Inhaler, Full peak absorption after ~3 minutes.
Gum, Full peak absorption after ~30 minutes.
Patch, Full peak absorption after ~60+ minutes.

That is a measure of the beginning of the efficacy.

[silverfox]

Holy Cow!!....someones been doin their homework..lol..