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Thread: Society for Research on Nicotine and Tobacco conference

  1. #1
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    Arrow Society for Research on Nicotine and Tobacco conference

    The SRNT Conference has just finished and some information was shared there on Ruyan research.

    Society for Research on Nicotine and Tobacco

    http://www.srnt.org/meeting/2009/pdf...r_Sessions.pdf

    1.) on page 139, abstract POS5-11:
    Laugesen (Health NZ): RUYAN NICOTINE ELECTRONIC INHALER/E-CIGARETTE: BENCH-TOP TESTS
    The abstract gives new information on the composition of the mist produced by Ruyan brand, indicating that nicotine delivery (16 mg carts) would be less per puff than from a regular cigarette.

    2.) on page 149, abstract POS5-50:
    Bullen (CTRU Auckland) et. al:
    EFFECT OF AN ELECTRONIC NICOTINE INHALER ON CRAVINGS, WITHDRAWAL, ACCEPTABILITY AND NICOTINE DELIVERY
    Abstract gives first results of a trial study, comparing Ruyan brand (16 mg), placebo, Nicorette inhalator and normal cigarette, regarding effects on cravings, some maximum plasma concentrations and speed of delivery.

    Also, the contact data of the leading authors is given...


    I've been asked to see if anyone can help with this question -

    "... how would the reported values for plasma concentrations appear in the time vs plasma nicotine diagramm (I remember you had such a standard diagram somewhere posted). Guess the units should read ‘ng/ml’ (typo?), but values appear somehow weird (very low)..."

    I think this is the graph being referred to:




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    Thanks a lot, Kate, for getting this information out. I was somehow irritated, when I first read the low numbers for peak plasma nicotine concentration reported in the Bullen et al. abstract. Thought, if they might have lost a digit, used different units, or whatever.
    Good you got that message from another professional (message from Eissenberg) , which set into perspective and confirmed that first data reported indicates relatively low effectiveness (of this specific Ruyan brand), indeed.
    Now, what this means for users, especially those who want to trade traditional cigarettes to vaping?

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    Hi Tom Thanks for the tips on links and contact with Dr Eissenberg.

    I think you're saying that your question has been answered by Eissenberg here - http://www.e-cigarette-forum.com/for...tml#post243540

    A discussion has started there about the low nicotine levels in blood found with the Ruyan research.

    I don't understand it myself, many people have reported nicotine overdose here but if the research is correct then that's very hard to do.

    I fully expect some people to start taking higher doses of nicotine because of these results.

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    Sooooooo - does this mean that Ruyan is going to submit this data to the FDA and commence the approval process to market/distribute (possibly mfg?) in the US?

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    Ruyan say that they do not sell tobacco products, they might use these findings to wiggle out of being a drug too. That leaves them uncategorised or a new category?

    That seems to be their strategy anyway and I'd trust them to have a good idea of legal possibilities. They've done all the work for vaping so far with research, I'm sure they're not doing it for nothing.

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    Yes, I think that Eissenberg put into perspective what has not been very clear to non-professionals (like me) from reading the Bullen et al. abstract.

    Quote Originally Posted by Kate View Post
    I fully expect some people to start taking higher doses of nicotine because of these results.
    That’s exactly why I was trying to be hesitant and dearly hoped that you might have got some answer.
    The ecig nicotine sword has two sides (at least): overdosing versus not too much nicotine to supress cravings (and back to pyro). The data out is just a report of the first results for a specific device and fluid. Nothing published, nothing independently confirmed. There’s also the other abstract by Laugesen, where he reports very different nicotine levels in the mist produced by two different devices. Anyhow, I now feel more comfortable than before when I read about extensive use (in strengh or vaped volume).

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    [quote=KateI fully expect some people to start taking higher doses of nicotine because of these results.[/quote]

    People are going to do what they do, If the nic is to strong they will back down. We have had enough people on here complaining about OD on small mg. Some of them could have been shills for the Anti's who
    knows. The only person that know how much is too much is the person taking the nic. some people only smoke a few cig a day and others smoke 4 packs a day. Lots of difference in people.

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    There's a possible upside here. I've been concerned that what I'm missing in vaping is some magic unknown chemical in smoke that makes analogs more satisfying, and no one is probably going to go looking for it to improve our product.

    This shows that there is some possibility that this may not be the case. Regardless, I'm not gonna be the one to try 160 mg/ml. What is that, like 16% by volume? It'd be a nicotine sludge.

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    The upside to this is that there is a study out there, done by an independent testing authority, that shows that the vapor produced by our PV's has minimal risks associated with it.....

    As long as the nicotine in the individual batches is closely monitored and tested for content control, a study such as this should have significant bearing to the FDA, HealthCanada, and some of the other countries looking for this kind of testing before OK'ing the products for sale..... If you check out some of the docs on embargo'd shipments coming into the US, that's the FDA's beef......these have not gone through FDA approval...

    The only question is - is this excerpt from the original New Zeland Study for Ruyan, or is this a new study to replicate the same results of the original? Because weren't there some "questions to the validity" of the original?

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    My theory of the low level of the nicotine spike is this.

    It would seem that Nicotine is best absorbed in an alkaline enviornment.

    Cigarette manufacturers add amonia to their cigarettes to aid in the absorption of nicotine in their cigarettes. E-cigarettes lack this function, so we need to consume more nicotine to actually absorb the same amount.

    How much of an effect this plays is questionable, and I don't have an answer for it.

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