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About LinkBacksHey, IANAN, boy, never know who you'll bump into when ya start roaming the streets at night. Anyway, don't these figures seem high? Not questioning accuracy, here, as I know you're exhaustive in your reasearch, but..wow!
Hey, IANAN, boy, never know who you'll bump into when ya start roaming the streets at night
Twisted... They could have grossly underestimated the numbers.... How many people go to a fast-food restaurant and order a sandwich smothered in ketchup with tomatoes, x-large fry and smoother them in ketchup and down it with a x-large Ice tea (42 oz= 5 1/4 cups)?? I really don't know any tea drinkers that only consume 1.6 cups a day.... more like 1.6 Quarts of tea a day.
Twisted... I see what you are talking about.... The Micro symbol didn't transfer over.... That should be ug and not g per day.
Wowzersif we are getting that much Nic...
Still think they underestimated it.
Hmmmm. Point understood. Sounds like I should up the ketchup on my prunes, then.
Originally Posted by IANAN
Twisted... I see what you are talking about.... The Micro symbol didn't transfer over.... That should be ug and not g per day.
Wowzers
Still think they underestimated it.
Oh......you sneeky guy. Had me going, there. Good. Scratch that ketchup, then
.
Well considering that50-60 mg is the lethal dose for humans... Documentation for Immediately Dangerous to Life or Health Concentrations (IDLHs) - 54115 then 1 g would be be enough to kill all us all several times over. Yeah I fixed it....
I'm not a doctor or chemist, but I can see a few quick reasons why tests calibrated for tobacco use would misread vaping:
1) Nicotine proper has a particular chemical formation, and refined nicotine will nearly all have that exact chemistry, but natural nicotine can be a mixture of slight variations (much like how all sugars contain glucose, and become glucose after digestion). Refined sugar is processed by the body much faster than natural sugars, which is why you see kids getting sugar rushes and crashes from candy. Something similar may occur with natural nicotine from tobacco and refined nicotine in vaping.
2) Tobacco delivers nicotine in particles of tar, which stick to the lungs and continue to deliver nicotine. PG and VG metabolize much faster, leaving less residual nicotine delivery.
3) Nicotine's effects are knockon effects on neurotransmitters and their receptors, which have residual effects of their own. These are not indicated by the test he took.
Note that although his nicotine level was not in the range of that of a smoker, his cotinine level was, and the 3-oh-cotinine level was elevated considerably above that of a non-smoker (although not at a clinically positive level). As cotinine is the short-term metabolite of nicotine, and 3-oh-cotinine is the long term metabolite, this is exactly what you would expect to see if vaping produced *rapid* absorption of nicotine but with little residual delivery, and the chemically pure form meant there was no delay as more complex forms were first metabolized into nicotine.
I'm not sure why so many people are suddenly trying to prove that vaping *isn't* actually delivering nicotine (unless some strategy against the FDA is involved), but this evidence certainly doesn't lean that way The cotinine result alone shows that significant amounts of nicotine were metabolized in the 2 weeks before the test, they would not have persisted for the two months since he quit analogs.
--Dave
I think this is awesome! I have personaly tried to smoke my old favorite analog once because my battery died... the result was me taking one puff and throwing the cig down, at this point it would not be possible for me to go back to analog's. However I do think the device you use to vape makes a huge diffrence as well, I'm a huge techy and anything I can tinker with and mod I enjoy, plus the quality is a big factor had I bought one of those cheap 50$ kits at the mall when I first started vaping I would probably not have been successful at my change.
whats cotinine? (and no. I dont wanna google it!)
Wicked self-study happily. Thats great information! Thanks for sharing.
One factor you didin't account for, what voltage do you vape at? As id imagine, higher voltage delivers more nicotine. Im guessing your vaping 3.7v for this study. Now try 7.4v and see what happens?
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