Question about Mg. Nicotine and E-Juice

[RoadRunner]

Originally Posted by Ultimist

No offense to those who said 60mg of nicotine is lethal... but that just isn't correct. It is 60mg per kilogram of body weight. BIG difference.

You should probably have checked your facts before posting.

In fact, I can prove that 60mg of nicotine isn't enough to kill. I vape the 36mg liquid exclusively... meaning 36mg of nicotine per milliliter. I vape between 4 and 5 ml each day, meaning I take in 144 to 180 mg of nicotine each day. If 60mg of nicotine is lethal, I hardly think I'd be able to take in 2 to 3 times that amount every day and still feel BETTER than I felt when I smoked analogs.

You are basing your "proof" on a number of misunderstandings.
Before posting in reply to your comments, I checked my facts and I include references here for all to see.
From:
inchem dot org/documents/pims/chemical/nicotine.htm

6.3 Biological half-life by route of exposure
The elimination half-life of nicotine averages 2 hours
(Benowitz, 1982; Feyerabend, 1985). The half-life of a drug
is useful in predicting the rate of accumulation of that drug
in the body with repetitive dosing and the time course of
decline after cessation of dosing. Consistent with a half-life
of 2 hours, accumulation of nicotine over 6 to 8 hours during
regular smoking and persistence of significant levels of
nicotine in the blood for 6 to 8 hours after cessation of
smoking, i.e. overnight, has been observed (Benowitz, 1982b).
Thus, cigarette smoking represents a situation where the
smoker is exposed to significant concentrations and possibly
pharmacological effects of nicotine for 24 hours a day.

You are spreading your dose throughout the day and thus, your body is eliminating your intake almost as quickly as you work to increase it. Your intake through vaping and your elimination through metabolism are near to being in equilibrium.
If this were not so, you would indeed, rapidly poison yourself.
... and this is why most of us want to smoke/vape more in the mornings... Because we've not been absorbing nicotine in our sleep, we've been eliminating it. Thus, we awake with lower plasma concentrations and then have a little bit of a binge to top our levels up then slow down after we've achieved our "comfort zone" once more.

Another misconception is in relation to the amount of nicotine in a cigarette.
Because cigarettes have a rating which indicates a strength, people assume that the rating refers to the nicotine content.
It does not. It refers to the amount of nicotine absorbed by a standardised "smoking machine" when "inhaling" on a lit cigarette.

3.1 Origin of the substance
Nicotine is a natural alkaloid obtained from the dried
leaves and stems of the Nicotiana tabacum and Nicotiana rustica,
where it occurs in concentrations of 0.5-8%. Cigarette tobacco
varies in its nicotine content, but common blends contain 15-25
mg per cigarette, with a current trend towards lower
levels.

The also applies to vaping.
Although a juice may be rated as 36mg/ml, we do not absorb 36mg of nicotine if we vape and inhale 1ml of juice. The amount of nicotine absorbed is far less per ml than the rating of the juice we are vaping.

Not only is your body eliminating the nicotine you are inhaling via normal metabolic processes, you're not absorbing everything that you inhale. What do you think is in the vapour that you exhale ?
I've seen people trying to claim that it is pure steam and this myth is passed from one scientifically illiterate individual to another faster than a reefer at a reggae party. I'm reasonably sure that my lungs don't achieve a temperature of 100 deg C.
... and finally - The facts which you misquoted.

7. TOXICOLOGY
7.1 Mode of Action
Nicotine is an agonist at nicotinic receptors in the
peripheral and central nervous system. In man, as in animals,
nicotine has been shown to produce both behavioral stimulation
and depression. Pharmacodynamic studies indicate a complex
dose response relationship, due both to complexity of
intrinsic pharmacological actions and to rapid development of
tolerance.
7.2 Toxicity
7.2.1 Human data
7.2.1.1 Adults
The mean lethal dose has been estimated to be 30
to 60 mg (0.5-1.0 mg/kg) (Gosselin, 1988).
7.2.1.2 Children
The lethal dose is considered to be about 10 mg
of nicotine (Arena, 1974).
7.2.2 Relevant animal data
Dog: oral LD50: 9.2 mg/kg
mouse: oral LD50: 3.3 mg/kg (RTECS, 1985-86)
rat: oral LD50: 50 mg/kg

For those unfamiliar with the term, "LD50" refers to the dosage which would kill 50% of test subjects. It's a kind of fancy way of saying "on average".
What this is saying is that if you were to absorb 60mg of nicotine into your bloodstream, it is highly likely that you will have succumbed to a dose which will lead to your death.
The fact that until now, no-one appears to have pulled you up on your error is rather worrying.
How many newbie vapers might have read your post and are now repeating a myth ?
How many veteran vapers have read your post and weren't instantly alerted to the glaring errors?

In my experience, the speed of fact is considerably less than the speed of fiction but hopefully I've helped to put the record straight... and if you're still convinced that 60mg isn't a lethal dose, drawing a couple of ml of your juice into an hypodermic syringe and taking it intravenously will put the record straight. However, you won't know the truth for long... Probably not even long enough to tell anyone.
Vape safely everyone.

Paul..
The RoadRunner..