Nicorette .5mg nasal spray...triggers intense cravings?

[exogenesis]

Thanks for the link Vaporista, I think you're spot on with that metaphor.

...
That running-around burn is what hits nasal snuff users when they start out. Eyes bulge and tear up. Eyebrows shoot up to the hairline. Mouth grimaces. And sneezing ensues. Keep it up and the nose gets very used to it. Only a slight burn with the good stuff.

Let us know how vaping nasal spray fluid works. I once diluted e-liquid to nasal spray strength, sprayed it into each nostril -- and it about blew my head off. Never again.

I assume TB diluted the e-juice with water then ?,
didn't think of that for nasal 'application', only extra PG.

Tell us how it works out Vaporer, be carefull how much you use though!
Perhaps we can combine nitroglycerine & nicotine in a sprayer
for a more explosive effect then
(actually it might, since it dilates the blood vesels).
Do you use nitroglycerine for angina ?

*Might* experiment with different amounts of water, to see if there's a
'half-way house' between superquick-nic-fix + burning your face off & nothing much:
24mg -> 10 mg with PG
24mg -> 10 mg with DI water
70mg -> 10 mg with DI water
70mg -> 10 mg with 95% ethanol
put 0.1 ml on a cotton bud and carefully apply nasally,
not going to spray it up there !

raddiver, I think it's absorb = 'soak up', like a cotton bud,
adsorb = 'adhere to a surface', so I guess vapour adsorbs to
your lung/oral/nasal membranes & the body absorbs the nicotine.

[Vaporista]

*Might* experiment with different amounts of water, to see if there's a
'half-way house' between superquick-nic-fix + burning your face off & nothing much:
24mg -> 10 mg with PG
24mg -> 10 mg with DI water
70mg -> 10 mg with DI water
70mg -> 10 mg with 95% ethanol
put 0.1 ml on a cotton bud and carefully apply nasally,
not going to spray it up there !

.

Might I suggest the possibility of a nasal gel like benzocaine topical a few minutes prior to nicotine administration on the site where the q-tip is applied. Maybe save yourself a world of pain
I looked into the benzocaine vs. lignocaine debate here but lets face it a nicotine spray is going places where q-tips/cotton buds fail to poke.

Results: We found that with respect to pain perceived on delivery of the sprays, lignocaine (Xylocaine) was significantly more painful then benzocaine (Hurricaine) with P < 0.05. In reducing the pain of the procedure itself, there was no significant difference between the 2. With respect to taste, smell, and acceptability, benzocaine did significantly better than xylocaine, P < 0.05. There was no significant difference when results were compared with reference to age, sex, or whether one was a smoker.

Conclusion: Benzocaine is better tolerated than Lignocaine as a topical intranasal local anesthetic spray.

Significance: When possible, choose benzocaine over lignocaine as a topical nasal anesthetic spray.

[Vaporer]

Thanks for the info Vaporista.

Exo, I was even thinking of a 3 way combo. The original eliquid, PG and water.
Something tells me ethanol is gonna be unpleasant. I've been wrong before.

I also have a couple expired nitro sprayers. Since the one persons experience transferred so well through mucous application....maybe the right mix a shot or 2 under the tounge and a bit of flavoring......bet you didnt see that coming, huh?

The only fail part I can see upfront is the "missing thing" we've discussed in other threads. I'm pretty positive it will work for the nic craving, but the not wanting in between factor. Where we vape almost constantly to keep levels constant, using a dissovable like Ariva or Stonewall helps that out, but if a snus is used the craving can be sustained for a longer period of time.

Something to a theory that there are substances in tobacco(snus) that relieve this and the further refined it gets (dissolvable then to nic liquid) those are removed and allow missing sensations to still occur that is beyond just nicotine.

A very small amount (&#37 of benzocaine, if needed, and might just be used in the solution.
It would have a slight delay, but we are also delaying the immediate effect also.

Edit: Can someone please get a pic of the FDA and ASH pulling thier hair out just reading this thread? lol

[exogenesis]

OK so we have: strong e-juice, dilute in water to 10mg,
add a bit of benzocaine, add a bit a of harmine as MAOI,
add some flavour.
Stick up nose (or under tongue) - Bingo...well maybe

Perhaps a suppository for the adventurous ?

Still might try....(not the last one tho)

[Vaporer]

Something tells me it would taste better orally......

I'd start with a min of components till the desired effect was reached and then work up adding others to tune it.
Less complications imo............

Edit: to much benzo could numb the olfactory and taste buds

[Vaporista]

Well whoever said the pain and agony of the spray does subside over time is not 100% correct. I'm now vaping almost 6-7 ml of 24mg juice and spraying anywhere between 1.5mg and 6mg of pure nic daily and have chosen the spray over snus and snuff after experimenting with both. For some wierd reason I will endure the pain. I don't understand it. But at least I'm still analog free and don't miss them at all (except when I get a whiff of someone smoking close- then it either smells gross or yummy depending on my mindset at the moment.)

[Mordred]

It feels like shooting Phosphoric acid directly into your brain via your nose.

Damn, now I want to try some.

[Vaporer]

Vaporista,
One thing we have found is that it doesnt seem to be all abt the nicotine.
That residual craving , even when upping the nic, seems to come from other things that has been called WTA. Whole Tobacco Alkaloids.
A test of the tobacco extract ie WTA liquid added to e liquid satisfies that itch you cant scratch in many people. They contain MAOI inhibitors. Just as addicitve if not more so than nicotine depending on the person. snus can be very helpful in these cases where people are addictated to the MAOI's as well or more than the nicotine.
More on it can be read here:
http://www.e-cigarette-forum.com/for...-new-post.html

[TropicalBob]

Exo, maybe you saw that Reynolds bought the pharma company called Niconovum a few days ago. This company has only three nicotine placement products: A snus, a gum and a mouth spray. It's that mouth spray that is of interest. I have yet to experiment with spraying a measured nic solution into my mouth, but I will.

When I did the nasal spray experiment, BTW, I did not dilute with water or alcohol or PG. I used the liquid already in a nasal spray container, designed to open nasal passages. I added e-liquid until I achieved the same level as Big Pharma's nasal spray. Burned like crazy!

And it should be noted that Dr. Jim Loi of Malaysia also tried nasal spray with e-liquid on some of his 300 e-cig testers. Alarmingly, he reported many developed inflammation after a week. That was when I ceased all nasal spray experimentation.

Course, I moved on to nasal snuff ...

[jj2]

Edit: Can someone please get a pic of the FDA and ASH pulling thier hair out just reading this thread? lol

I want to see that.!!!