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Nicotine Replacement Therapy Talk about the various forms of NRT. Give people the heads-up on cheap sources/suppliers.

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Old 10-30-2009, 04:51 PM   #1
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Default Nicorette .5mg nasal spray...triggers intense cravings?

Cravings.....I've not had any cravings since quitting smoking and going direct to 24mg juice, but after a few weeks, I finally had the courage to try one of the few bottles of 0.5mg Nicotine nasal spray I have lying around...Just for a change more than anything else...I say courage because you need it when you try this stuff.
It feels like shooting Phosphoric acid directly into your brain via your nose. You start with good intentions. In my case I want a 1.5mg nicotine dose so that's one squirt up each nostril and one extra squirt. (these are measured sprays) So. I spray the first and before I can even pull the applicator out to spray the second, such unbelievable pain stops me in my tracks. I can't move a hand. Hell I've been Taser'd. My brain sizzles. I want to scream but I can't. My nostrils have been flooded with concentrated Habanero oil and the fire is whooshing through sinus passages I never thought I had... The stuff is probably blazing new trails through my head.
Think red hot poker that has been dipped in napalm and shoved up your nose... That's what it feels like. Then I notice my feet start stamping all by themselves and suddenly my eyes flood with tears. I can't see a thing but I can feel the huge wet warm rivers running down my face. It takes several moments before I can blink my way clear. Maybe that was my bodys inner fire extinguishing system backwashing out through my eyes.
Then the stinging starts. I hear it first though. it's the sound of the first few drops of cold water hitting a smoking skillet. Then comes the avalanche of acupuncture needles, discharged from what seems like a shotgun somewhere near my mouth and they sting evey milimeter of exposed tissue in my mouth, nose and all spaces in between. I repeat the process in the other nostril. By now, when I open my eyes I see that I'm halfway down my driveway. I don't have the courage for a third squirt. The post nasal drip starts almost immediately and I run back inside the house looking for something to get the godawful taste out of my mouth.
I empty a mug of hours old cold coffee.
And within moments I feel a calmness. A warmth. A serenity even. I feel good.
Now a few hours later after vaping 24mg I get a craving for cigarettes. But this cannot happen. It's not an option. I change juices. I vape more, but the nicotine craving won't be quieted. I eye the nicorette spray next to me and I contemplate going through hell again for a fix. Hell doesn't seem so bad considering the peace I'll feel after the spray. So I gather my courage and here we go again... Poker iron glowing red

Note: The product is Nicorette Nasal Spray manufactured by Pharmacia LTD in the UK. Contains 200 sprays of 0.5mg Nicotine in a 10ml bottle containing 10g/ml nicotine.

I've been planning to Vape this supply of mine, but I can't seem to get the courage to do so after Tropical Bob's dilution experience...
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Last edited by Vaporista; 10-30-2009 at 05:10 PM.
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Old 10-30-2009, 07:06 PM   #2
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I know what you mean. It's akin to being stabbed in the skull with a blunt spoon
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Old 10-30-2009, 10:33 PM   #3
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I've always thought these were the most effective yet most un-usable
NRT out there, as long as you can stand the intense burning nose thing,
which I can't.

Basically its's 10 mg/ml quality nicotine in water
(+ other 'formulation' chemicals as below).
About 10 ml for about £15 = not so different to juice price.

You certainly don't get the insta-nicotine if you put the
same amount of 10 mg/ml PG juice up your nose (don't ask).

But vaping it ?, I'd be cautious,
3 possible things I can think of that might occur:
1 you either lose it all out of your atty (too thin)
2 it'll not work in the atty at all - too much water?, nicotine all destroyed on coil ?
3 it'll work so well you get a excessive 'effective' dose,
i.e. without the 'moderating' effect of PG/VG, and horrible
burning in your lungs - eek!

Wonder which it would be ?

Ingredients:

10 mg/ml nicotine

Preservative:
Methyl And Propyl P-Hydroxybenzoate

pH modifiers/stablilisers:
Disodium Phosphate
Sodium Dihydrogen Phosphate
Citric Acid

chemistry modifiers/stablilisers:
Sodium Chloride
Polysorbate 80
Disodium Edetate (EDTA)

beta-Ionone (rose perfume)

Water
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Old 10-30-2009, 11:48 PM   #4
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[quote=exogenesis;689048]You certainly don't get the insta-nicotine if you put the
same amount of 10 mg/ml PG juice up your nose (don't ask).


Ask. Guessing you'd recommend against this?
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Old 10-31-2009, 12:43 AM   #5
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exo,

I have a few metered sprayers and had considered this. It could even be flavored.
Did you notice any long term nic adsorbtion? We know vaping is slower to adsorb. this seems to support the PG/nic bonding from the determining nic thread.
http://www.e-cigarette-forum.com/for...-new-post.html

I read the other day here somewhere that a person used the nasal inhaler in the mouth and it adsorbed very quickly.
If the burn is that bad, seems a 50% dilute wit a little flavoring 2x an hr might be not so bad.
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Old 10-31-2009, 01:52 AM   #6
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Quote:
Originally Posted by Vaporer View Post
Did you notice any long term nic adsorbtion? We know vaping is slower to adsorb.
I would think that the nrt would absorb while vaping would be adsorbing.

or maybe im just not understanding the questions because adsorb and absorb are slightly different.
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Old 10-31-2009, 02:24 AM   #7
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Yes, if the slow release we all experience with e-juice is all
down to the 'encapsulating' effect of glycols (PG/VG/PEG),
and nic. does get to the bloodstream, but on 'slow release'
cf quick release with water/alcohol solutions,
then maybe a weak version of this could be usable,
as long as you could put up with/mask the unpleasant effect.

The nasal spray chucks out 0.5 mg nicotine (for each nostril squirt),
in about 20 to 50 microlitres per squirt, vaping gives 6 microlitres e-juice per 60 ml puff,
(DVap's determination) so for 36 mg/ml this is 0.2 mg nicotine, so 5 vape-puffs
equals the nic. in one double-squirt dose.

People repeat-vape, & you certainly can't 'squirt' sequentially very frequently.

I'd say if you were to try inhaling this aqueous nic. solution, you'd want
to dilute it far more than 1 in 2, to avoid horrible 'burning'.
What degree of 'unpleasantness' did the person who took it orally experience?


btw where is Tropical Bob's 'dilution' experiment, anyone got a link?
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Old 10-31-2009, 02:59 AM   #8
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exo,

He said it was nasty tasting...well it wasnt meant to go on taste buds....lol
He described a slight burning instant nic hit.

Reminded me of a nitroglycerine sprayer , shoot....5-10 sec till effect.

I havent tried the nic spray, just ran the math. Its feasible if diluted to the point of not shoving a soldering iron up your nose. Water may or may not be the best carrier.
Certainly PG/VG/PEG is holding adsorption. PGA may be a good alternative.

Due to what gets in, time isnt really a big factor as long as its not to slow.
If it took 4 per nostril in an hr without discomfort, some may leave PV's altogether!
Others may still like the vape and just use 0nic for the oral fixations.

I still like the idea for flavoring it though. Dry snuff is flavored and can linger for 10-15min after use.

Looks like my Flonase sprayer is coming apart lol I'll have to claibrate it with each batch since its output will change with viscosity. I have a couple of emptys.
I dont throw anything away.......my wife does not understand this.

With no heating loss the concentration should be able to be reduced.
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Old 10-31-2009, 08:37 AM   #9
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Quote:
Originally Posted by exogenesis View Post
The nasal spray chucks out 0.5 mg nicotine (for each nostril squirt),
in about 20 to 50 microlitres per squirt, vaping gives 6 microlitres e-juice per 60 ml puff,
(DVap's determination) so for 36 mg/ml this is 0.2 mg nicotine, so 5 vape-puffs
equals the nic. in one double-squirt dose.

People repeat-vape, & you certainly can't 'squirt' sequentially very frequently.

I'd say if you were to try inhaling this aqueous nic. solution, you'd want
to dilute it far more than 1 in 2, to avoid horrible 'burning'.
What degree of 'unpleasantness' did the person who took it orally experience?


btw where is Tropical Bob's 'dilution' experiment, anyone got a link?
Link Nicotine Inhalator
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Old 10-31-2009, 09:02 AM   #10
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Quote:
Originally Posted by exogenesis View Post
beta-Ionone (rose perfume)

Water
I don't have the ingredients list but my batch is from 2007 and I'll tell you there is no chance that it smells anything like rose It is unflavoured -just a strong medicinal type horribly unpleasant taste.
I suppose this 0.5mg metered spray is the crack cocaine of the nicotine world, I have been trying for a dose of 1.5 mg which is equiv of one normal Peter Stuyvesant Red cigarette but unfortunately the agony of the spray is too unbearable to get in three squirts in rapid sucession.
I've been using it two days now and the pain has not diminished, neither has watering eyes, and that automatic hands above the head reflex once the first couple of sprays have been discharged.
I'm on 24 mg juice (haven't tested the 36mg to see if your 5 vape= 1 squirt theory is true- but somehow I doubt this even though the math says otherwise) and I could vape 24mg all day and not get the effect that a double squirt of the 0.5mg spray has after 120 seconds.
EDIT: I managed to get 1.5mg (three squirts) in and the effect after 120 seconds is a feeling of intense wellbeing but those 120 seconds were the worst of my life. I now know how the poor bunnies being tested for shampoo/cosmetics must feel
What is interesting is the effects drop off very quickly and leave a certain "shakiness" for lack of a better word and yes cravings for more. The e-cig takes the edge off though but I think the brain is expecting a bigger dose of nicotine. E-cigs are sustained release nicotine pills while the spray is the nicotine intravenous injection
This metaphor works...
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