The potential for abuse or addiction to a drug
is generally determined by the magnitude of the posi-
tive reinforcing effects and the speed of drug deliv-
ery to the brain.18 Typically, the relationship between
drug dose and the reinforcing effect of the drug is
characterized by an inverted U-shaped curve.15,18
Administration of an addictive drug will increase
until its toxicity reduces the overall desirable effects
and therefore decreases its reinforcing effects.
Generally, the more quickly the drug is delivered to
the brain, the greater the potential for abuse.23
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