When I switched from an RJR brand of cigarettes (Misty Lights) to a comparable Indian cigarette, I had bad withdrawl from "something" - no matter how many I smoked. I am also lacking that "something" with vaping, even though I have, at times, taken in enough nicotine to make myself sick.
So it is not just the nicotine, or vaping or the patch would satisfy me. Nor is it something in natural tobacco - MAOIs or one of the naturally occuring alkaloids, or else the Indian cigarettes would have satisfied me.
Nothing scientific, just my own limited experience - but I assume there is "something" in commercial cigarettes that is not in natural ones. Then again, it might not be chemical at all, it could be something psychological between us and our brand of choice. That would be almost impossible to figure out, and would be different for each person.
~A



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