well, i guess it depends...
if you're going to use a ss mesh wick, you have to make sure you oxidize it very well (or at least the part the coil will touch). i believe most people try to do this anyways, so not really a huge difference, but with a mech it is possible to pulse oxidize the wick and coil (this is generally what i do).
you also have to ensure that your coil is at or above something like 1.5 ohms. again, there are a lot of people who will wrap their coils around 1.5 regardless of what they're using it on, but you don't have the option of going lower on a regulated mod.
all that being said, you can still get great performance out of a regulated mod and an rba. i started with an aga-t2 on a vamo (the aga-t2 is still a pita for me to set up...), and once i got it working properly, the flavor blew my mind.