It's interesting to ponder that the importance of the other alkaloids might be mainly
through their ability to amplify / speed up the nictonine effect; that the problem with NRTs such as the patch, and even traditional
e-liquid, is not after all so much that nictine is not the key, but the importance of rate of change was overlooked. That is, the body recats to changes more than absolure levels. Change something too slowly and it goes unnoticed (like the boiling frogs).