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Diacetyl, Acetyl Propionyl, and Acetoin in Flavorings with data

Published by RocketPuppy in the blog RocketPuppy's blog. Views: 1604

There are more than 2,000 substances used in flavoring manufacturing. The FDA regulates flavorings to ensure they are safe when eaten. Many flavorings have been in longstanding use and are classified by the FDA as "Generally Recognized as Safe" (GRAS) to eat. Thus far, the FDA does not require testing for other routes of exposure, such as inhalation.

Some flavoring manufacturers are using alternative substances for diacetyl in formulating flavorings. These compounds are acetoin and acetyl propionyl. Like diacetyl, these are 'GRAS' substances that are approved for use in food. Their chemical structures are very similar to diacetyl and have been found to be equally as harmful for inhalation.

Companies are not required to report if their flavorings contain less than 1% of diacetyl or diacetyl substitutes (

Two companies (FA and TFA) have shown that in quantities with less than 0.5%, 1000s of ppbs have been found, yet NIOSH recommends the exposure limit (REL) for vapor inhalation up to 8-31 ppb.

CDC - NIOSH flavorings exposure
OSHA- Diacetyl and Diacetyl Substitutes
FDA New Authority on E-cigarettes

Department of CA Diacetyl Report of Use
Diacetyl Standard Becomes Official - Cal-OSHA

FlavourArt Clearstream

TPA Spec Sheet and Components 513-86-0
TPA Spec Sheet and Components 600-14-6

IJ - Impact of Flavor Variability

VP LIVE - interview

Flavor and Manufactures Association Updated List April 28, 2014
FEMA flavor - Safety/Assesment/Regulatory Flavors (E-Cigarettes)
Perfumer/Flavorist Fema

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