There is not yet sufficient science to assure "Safe", but there is enough to at least improve on "safer"
The latest study I saw is that they got together a large number of doctors and/or scientists and locked them in a room until they came up with a percentage risk for various forms of drugs. That is a surprisingly accurate method even though there is no real evidence, but it's informed guesswork of course.
e-cigarettes came out with a 4% risk, of which around half was due to the perceived dangers of being addicted to something.
I'm happy enough being dependent on nicotine, so there's 2% I need not worry about. (And even that is contended.)
The thing is, there is no known risk to vaping. We always say it is safer than smoking, not risk free, but those risks are unknowns; there may be damage we are doing to our lungs or some other organ that will only become apparent decades down the line. But with what we know now, it is perfectly possible that there is no such damage, that we could vape like a steam train for a century without hurting ourselves.
There is DA/AP in cigarettes, but smoking is already dangerous. If DA/AP kills 1% of its users, then that is a tiny added risk considering that smoking as a whole kills 50% of its users. If it eventually emerged that vaping kills 1%, then I imagine that many of us would accept the damage we are doing to ourselves; we are well aware that this activity, while almost certainly safer than smoking, is not proven to be risk-free. But it may be entirely safe.
Which is why DA/AP is so important. It is a risk that is not necessary against a possible background risk of 0%. The more research that is done and the quicker the industry acts to contain such discovered dangers, the more likely we are to be able to continue to enjoy this hobby entirely safely.
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