If you've owned a retail business, you know that a large portion of that markup is gobbled up by rent. Here in L.A. non-prime storefront space in a decent (meaning not ghetto) area adjacent to, but not on, a main drag is averaging 3$ sq. foot. for locations with street parking only. Locations with dedicated off-street parking can run significantly higher. Doesn't sound like much, but it equates to $3600 mo. for a 1200 foot store (no parking, off main drag).
And that's at the cheap end. You want to go prime location with a vape shop, good luck. Just a main drag, or anywhere within 500 feet of a metro station, will double the rent, parking or no. "Premium" retail areas like "old town" type districts are basically untouchable for a vape shop. I just checked out an 1100 ft. storefront in "Old Town Pasadena" great area, huge pedestrian traffic day and night...$9,400 per month (no parking, not even an employee parking area)!
Now, a vape shop could go cheaper by going ghetto, or going to a retail no-man's land, but only with significant added risk. Could also go smaller, 800 sq. ft. should be sufficient for a retail-only (no online sales) vape store. Problem in L.A. is there's a huge demand for small retail because everyone and their mother wants to open an 800 sq. ft. sandwich shop/coffee house/cupcake boutique, so small locations in good areas are very challenging to find.
Notwithstanding regulatory hassles, the best bet for a vape shop is a small shop in a funky area, maybe with used book-record stores, tattoo parlors, etc. for neighbors, that isn't undergoing or is unlikely to undergo in the near future, gentrification, preferably with a studio apartment above the shop included (to run your online side-business at night), because there ain't gonna be no income sufficient to be paying home mortgages and the like. It'd also be wise to go ahead and add hookas, zig-zags, crack pipes and psychedelic fluorescent glow in the dark posters to your inventory, just to like build a protective .... around your little empire and hope it's enough to keep the regulatory waves at bay.
But why go through the hassle and heartache when you can just pay a guy the equivalent of a couple month's rent to set up a website for you and sell stuff online out of your apartment?
Vape shops were pretty much doomed from the start, though I admire the audacity of those who turned a blind eye to impending Regs and opened up anyway. But nowadays it's like Rommel blitzkrieging through the desert..."We don't need gasoline! We can Win!" Well, look what happened to Rommel.