Hey Mr. Mann...
I saw your question on the general WTA discussion thread,
"From what I understand, nornicotine and cotinine are both minor/secondary alkaloids and metabolites of nicotine, but nornictoine is in a fairly high percentage of the famous "5%". I am finding conflicting information about whether nornicotine even has any MAOI effects--most of what I can tell is that it mostly "acts" like nic. I guess what I am asking is that if nornicotine is a "major" minor alkaloid, but it doesn't seem to be all that impressive for the part that we're looking for when vaping WTA, is its presence needed? Or is this the scenario where isolating a specific alkaloid would be too prohibitive and just not worth the hassle?"
Thought this study probably confirms your impression that nornicotine seems to have less synergistic effects with nicotine than the other prevalent minor alkaloids...at least in rats.
The addition of five minor tobacc... [Int J Neuropsychopharmacol. 2009] - PubMed - NCBI
Dude, I was right about to re-post that here. Too funny.
Oh, and I have that same study open up on my computer already. LOL Although, mine is from http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=6382912 (same study though).
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