I was a 2+ PAD smoker and tried with the 12 mg liquid. I still had the craving to smoke, so quickly ordered a selection of 18, 24, and 36. 26 is a heavy hit and makes me kind of nauseated and dizzy. 24 seemed about right, but a bit strong. I'm currently cross-mixing, which gives some very interesting combination flavors, and hitting about 18-20. That works for me.