Which I iTaste is 30W and 2200mah? Or are you referring to the iStick 30? I definitely think the Heatvape Defender's 2600mah is an advantage, and I don't need anything over 25 watts in power, even for when I tried near "sub ohm" vaping.
As to sub ohm'ing, it is not for me, but the tanks for it still interest me. I got a Subtank Mini not long ago, using the 1.2 ohm heads on it. It is too hot running for me, with very strong TH, even at lower than recommended wattage levels. Luckily it comes with a good build deck, and I'll try maybe a 1.7 ohm twisted 32 gauge wire build on it - when I get a chance. The Subtank Mini is a pretty nice 4.5ml juice capacity tank, but all its prebuilt heads are unsuitable for very good mouth-to-lung hit vaping, at least for me.
For now I still use the Mini Nautilus with the old style BVC heads. It is okay, but doesn't wick as well as I'd like. Does Vapor Alley have the newer, larger wick hole, Nautilus BVCs coil heads yet? I'd like to get some of those.
For the moment I'm using my mini box mod with the Mini Nautilus (as imperfect a topper as it is), and a regular little 650mah eGo battery with 2.1 ohm iClear 16 toppers (which would be nearly perfect if they held more juice). They are both very similar in relative vape quality after dialing everything in to my tastes.
I run the little iClear 16s on the mini box mod as well. These mini box mods are pretty flexible pieces of equipment. You don't need to sub ohm with them, but you can if you want.
The higher power demands of higher performance vaping make the Defender 25W a pretty good choice with its 2600mah battery, but that is worthwhile for low wattage vaping too. The Defender can go down lower in power than the iStick 30, but I don't need to go quite that low myself.