I saw your post regarding your review of the FDA report. I have been reading on the subject of nicotine metabolites, how they are present in eliquid, and what effect inhaliation of foodgrade flavorings might have on the body. I understood what you were getting at, that you were not attempting to state that eCigs are safe, but that there were faults with the njoy study design. Yes further studies using animals for toxicity of these inhalants should be used, even if the carcinogenic metabolites are merely in trace not measurable amounts. I trust the eliquid vendors I use, but I do wonder what kind of independent testing they undertake on their products regarding nicotine concentration, etc. The industry should do more to band together to develop standards to lend itself such legitimacy, and to foster more academic studies into the very questions you pose. (con't)