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Another possibly important oxidation product of nicotine - nicotinic acid - via pyridine
"Nicotinamide, a form of the B vitamin niacin, is known to exert similar effects on the brain as benzodiazapenes.13 Nicotinamide stimulates the GABA-benzodiazapene receptor complex, an inhibitory neuron grouping. By activating these neurons, a calming effect is the end result.14 Other... -
More on the importance of cotinine relative to nicotine
Thinking about the relative nature of smoke and vapor. Smoke will contain other alkaloids beside nicotine, but what nicotine is released is more likely to be oxidised than the nicotine in vapor (because largely the 'vapor' is mostly actually a mist of tiny droplets of PG/VG with the nicotine... -
Comment by 'kinabaloo' in 'Cotinine - its importance in success of vaping compared to traditional NRT'
Thinking about the relative nature of smoke and vapor. Smoke will contain other alkaloids beside nicotine, but what nicotine is released is more likely to be oxidised than the nicotine in vapor (because largely the 'vapor' is mostly actually a mist of tint droplets of PG/VG and less susceptible...- kinabaloo
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Cotinine - its importance in success of vaping compared to traditional NRT
One wonders about the anecdotal evidence regarding the advantages of: 1) 'steeping' and 2) high power vaping - and whether there might be psychopharmacological advantages to oxidation / heat induced changes (beyond improvements in taste). This paper is interesting ... -
Comment by 'kinabaloo' in 'Beta Carboline MAOIs - towards a more effective e-liquid'
What I think more likely is that the acid-base extraction doesn't favor any particular alkaloid (I could find no reason to suspect it might) and the explanation for the different alkaloid profile is that in smoking, the 'MAOI' alkaloids (or the 'others') are less readily evaporated than nicotine...- kinabaloo
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Comment by 'kinabaloo' in 'Beta Carboline MAOIs - towards a more effective e-liquid'
It would be good to determine if / to what extent the grinding of the tobacco is important for yield - perhaps less than one would think. Perhaps extend the period to compensate. With the hot oil approach in particular, maybe the fine grind is unnecessary?- kinabaloo
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Comment by 'kinabaloo' in 'secondary extraction to the tobacco with excess water'
Either the more volatile (?) non-polar sol vent is better at dissolving non-alkaloids (in which case the color would largely disappear on the second stage) or, more likely, the darker color is from the alkaloids being much more oxidised in this second run (and 5 day steep).- kinabaloo
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Comment by 'kinabaloo' in 'Microwave-assisted extraction of solanesol from tobacco leaves'
Re the limitation - a longer settling period could help (before drawing off the oil layer).- kinabaloo
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Comment by 'kinabaloo' in 'new method increases yield and the elimination of water increases reliability'
This is a great innovation. I think your complete method, with all it's tips and carefully devised honing of the acid-base extraction method to the WTA purpose, is about as good as a home method can get - i.e. not much short of what a lab could do.- kinabaloo
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Comment by 'kinabaloo' in 'Kitchen WTA extraction method.'
WTA seems to be high in the 'other' alkaloids relative to nicotine (a different profile to that in smoke, and in my eyes, preferred). My extraction using a very similar method was around 4-5 mg and had little nicotine that I could notice, but a big effect in terms of a 'wave of calm' that...- kinabaloo
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Just seen the Flavaah in my local shop - any one tried this ?
Seems very new - Googled it, nothing. Looks like a tank system. Price £15. Shop sells many flavours of liquids too - first time to see liquids on sale in a normal shop (handy for carts too). What's your Flavaah? Aromatic liquids for electronic smoking devices Has a picture but not much else.- kinabaloo
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- Forum: Requests for Opinions/Reviews
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How WTA from Aroma Ejuice make me feel
That's exactly to be expected - if nic alone does the trick, there will be little difference noticed between the two; but when nic. alone does not work out, the difference is very noticable, to that person. Briefly, nic is more a stimulant whereas WTA has additional qualities perhaps... -
MSM smokescreen
First log-in for over a year, but this just made my blood boil ... Watch out, e-cigarette smokers ps: e-cigs seem to have finally taken off in the UK over the last months :) pps: saw a post about helping find the cure for cancer - sorry, but that has been found many times already and will...- kinabaloo
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- Forum: General Vaping Discussion
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Kurt on the VapeTeam tonight 12/21/11 9:30EST
Doubt anyone would be interested in self-serving elitists' grandstanding when they didn't bother to update here where people were asked to send donations. When the BE thing was hot and the call bto arms made for more testing, people were dumfounded to hear that the activity was not testing...- kinabaloo
- Post #3
- Forum: QC Research and Testing
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Chinese Tobacco Juices... How do I mix this juice to eliminate the taste of dirty gym socks?
Although the 'red label' is from China and still TW's biggest seller (afaik), they are not averse to playing the China fear game. It's one of the things I dislike about TW - being two-faced just to make a bigger buck :( Here's what they say : "When electronic cigarettes first came onto the... -
WTA is the future
It's a bit exaggerated. 2ml VG / 1g tobacco is workable. The main issue is that the alkaloids extracted will be in dissolved salt form, which have a lot less impact. I might try 1 drop of saturated sodium carbonate solution / 2ml VG (about 1 part in 40 or 2.5% v/v). VG might attain higher... -
Blood circulation and nicotine....sad....
Two things to llok into as supplements to help with any circulatory issues : Vitamin D (may even be able to reverse arterial plaque to some extent; one of the many important roles of this hormone is to take calcium from the blood/arteries and put into bones where it belongs.) You can safely...- kinabaloo
- Post #38
- Forum: Health, Safety and Vaping
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WTA is the future
I think the reason is not that toxins simply become harmless at low levels by some kind of magic, but that the body can cope with detoxifying and damge repair to a certain extent before it gets overwhelmed - something where many factors / toxins all add up. For a number of reasons, it would... -
WTA is the future
Air-cured tobacco is hung in well-ventilated barns and allowed to dry over a period of four to eight weeks. Air-cured tobacco has a high nicotine content. Cigar and burley tobaccos are air cured. Fire-cured tobacco is hung in large barns where fires of hardwoods are kept on continuous or... -
WTA is the future
Not tried these liquids; just going by the info provided.