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Comment by 'kinabaloo' in 'Kitchen WTA extraction method.'
Quick reply; maybe more detailed later. It is great that you are thinking of improvements - that's the whole point, although I think it is very good as is. Re 'unknown concentration of alkaloids' - yes, tobaccos vary but one can look up the tobbacco one is using and be pretty sure of the...- kinabaloo
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Comment by 'kinabaloo' in 'Kitchen WTA extraction method.'
Having thought more about it, DVap is welcome to the WTA term, as the creator of the aronym. But I'm not interested in his opinion on this method as it is clear from years of silence that it would be considered 'competition' and slighted. No problem with commercial enterprise, just done fairly...- kinabaloo
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Summary on the importance of oxidation in vaping
In summary on cotinine and niacin - cotinine might be the main benefit giving constituent, and minus the negatives of nicotine (e.g increaded heart rate), with niacin as the MAOI component. Steeped e-liquid more like WTA (though not it's equal, maybe not too far off?) That some nicotine will... -
Comment by 'kinabaloo' in 'Another possibly important oxidation product of nicotine - nicotinic acid - via pyridine'
In summary on cotinine and niacin - cotinine might be the main benefit giving constituent, and minus the negatives of nicotine (e.g increaded heart rate), with niacin as the MAOI component. Steeped e-liquid more like WTA (though not it's equal, maybe not too far off?) That some nicotine will...- kinabaloo
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Comment by 'kinabaloo' in 'Another possibly important oxidation product of nicotine - nicotinic acid - via pyridine'
Looking like the original science on smoking, focussed solely on nicotine, was flawed in two ways over - it ignored the other ('minor') tobacco alkaloids; it ignored the role of oxidation and the oxidation products (there's overlap). These ignored chemicals might even turn out to be the major...- kinabaloo
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Another possibly important oxidation product of nicotine - nicotinic acid - via pyridine
"Nicotinamide, a form of the B vitamin niacin, is known to exert similar effects on the brain as benzodiazapenes.13 Nicotinamide stimulates the GABA-benzodiazapene receptor complex, an inhibitory neuron grouping. By activating these neurons, a calming effect is the end result.14 Other... -
More on the importance of cotinine relative to nicotine
Thinking about the relative nature of smoke and vapor. Smoke will contain other alkaloids beside nicotine, but what nicotine is released is more likely to be oxidised than the nicotine in vapor (because largely the 'vapor' is mostly actually a mist of tiny droplets of PG/VG with the nicotine... -
Comment by 'kinabaloo' in 'Cotinine - its importance in success of vaping compared to traditional NRT'
Thinking about the relative nature of smoke and vapor. Smoke will contain other alkaloids beside nicotine, but what nicotine is released is more likely to be oxidised than the nicotine in vapor (because largely the 'vapor' is mostly actually a mist of tint droplets of PG/VG and less susceptible...- kinabaloo
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Cotinine - its importance in success of vaping compared to traditional NRT
One wonders about the anecdotal evidence regarding the advantages of: 1) 'steeping' and 2) high power vaping - and whether there might be psychopharmacological advantages to oxidation / heat induced changes (beyond improvements in taste). This paper is interesting ... -
Comment by 'kinabaloo' in 'Beta Carboline MAOIs - towards a more effective e-liquid'
What I think more likely is that the acid-base extraction doesn't favor any particular alkaloid (I could find no reason to suspect it might) and the explanation for the different alkaloid profile is that in smoking, the 'MAOI' alkaloids (or the 'others') are less readily evaporated than nicotine...- kinabaloo
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Comment by 'kinabaloo' in 'Beta Carboline MAOIs - towards a more effective e-liquid'
It would be good to determine if / to what extent the grinding of the tobacco is important for yield - perhaps less than one would think. Perhaps extend the period to compensate. With the hot oil approach in particular, maybe the fine grind is unnecessary?- kinabaloo
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Comment by 'kinabaloo' in 'secondary extraction to the tobacco with excess water'
Either the more volatile (?) non-polar sol vent is better at dissolving non-alkaloids (in which case the color would largely disappear on the second stage) or, more likely, the darker color is from the alkaloids being much more oxidised in this second run (and 5 day steep).- kinabaloo
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Comment by 'kinabaloo' in 'Microwave-assisted extraction of solanesol from tobacco leaves'
Re the limitation - a longer settling period could help (before drawing off the oil layer).- kinabaloo
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Comment by 'kinabaloo' in 'new method increases yield and the elimination of water increases reliability'
This is a great innovation. I think your complete method, with all it's tips and carefully devised honing of the acid-base extraction method to the WTA purpose, is about as good as a home method can get - i.e. not much short of what a lab could do.- kinabaloo
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Comment by 'kinabaloo' in 'Kitchen WTA extraction method.'
WTA seems to be high in the 'other' alkaloids relative to nicotine (a different profile to that in smoke, and in my eyes, preferred). My extraction using a very similar method was around 4-5 mg and had little nicotine that I could notice, but a big effect in terms of a 'wave of calm' that...- kinabaloo
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