OP, I think mayhaps the question is mis-formed. Flavor and vapor production, and juice use go hand in hand.
To maximize economy, use finer wire and higher ohm single coil builds on lower airflow atties. Low power builds = low vapor production, low flavor, low juice use.
To maximize flavor, use larger wire, lower ohm, multiple coil builds on higher airflow atties. Meduim power builds = medium vapor production, medium to high flavor (kayfun and ilk), and medium juice use
To maximize vapor, use the largest wires, lowest ohms, most coils, highest airflow. high power builds = high vapor production, medium to high flavor (it really depends on too many things at this level to be specific) and high juice use.
These are over-generalizations for sure, but my point was more to help you understand that what you are asking for are two mutually exclusive ideals.
I don't believe this is accurate... I'm no expert, so this isn't law, just based on my experience/what I've read.
There are flavor attys and cloud attys and some that give great flavor and decent clouds.
Generally a smaller build space gives you better flavor i.e. smaller deck / smaller RDA (18mm or so instead of 22mm) like a K6/cyclone or A7 (not sure if its actually 18mm, thats just an example).
Also, Lower ohms/thicker wire go hand in hand, but the fatter wire has lower resistance so takes longer to heat up if built at the same ohms as a thinner/higher gauge wire.
Airflow is important, having lots of airflow (like doge or something with crazy airflow) on a coil with large surface area will give you bigger clouds (hence fatter wire). having tighter airflow.
Using ohms law you can up the power/heat/watts (all the same thing for our purposes) by lowering your ohms - true... but if you have a regulated mod you can up the Watts to give you a hotter vape without dropping your ohms, the heat is just more concentrated. Heat Air and Liquid make vapor. Hotter coils means more liquid vaporized faster, given the appropriate amount of airflow. Building higher ohms will use less amps and watts making your battery last longer, and with a tighter draw you can effectively vape less liquid and potentially get good flavor. The atty has to be designed for it though. I think the plume is meant to be a good mix of flavor and vapor. The vapor tastes different at different temperatures in different attys. mouth to lung hits usually allow for a lot of good flavor without costing a lot of vapor. You also get a bit more nicotine per drop of juice vaporized as it spends more time in your mouth where the nicotine is processed into the body. The vapor particles are larger than smoke so your lungs don't absorb the nicotine as well (if at all). Sure, you get more of a nic buzz when cloud chasing, hence cloud chasers using lower nic levels, but that has more do with the volume of juice vaporized/vapor inhaled than anything else I believe.
Feel free to correct me if I'm wrong. Not trying to be a jerk, just trying to be helpful
I like 28 ga single coils built around 1.2-1.6 as the ramp up time is low (no powered primer puffs to get the coils "going"). Dual coils I build around for a net of .8ohms (2 1.6 ohm coils). Depends on the atty of course, as I like a dense cool vape - so smaller decks get higher ohms and less voltage/wattage