Yup, depends on the juice and the output. If using light colored or low flavor % mixes, I can get about a week before any significant change in flavor or vapor production, and then dry-burn and re-wick with fresh cotton. Darker juices & NET's, I usually re-wick everyday to everyother day, and rebuild every week or so, depending on how bad the coil is. Some flavors don't dry burn off the coil after a while and the more times you have dryburned the coil, the faster it will gunk up, so I just wind up a new microcoil and am good to go.