Data: Was a 25 year 3-4.5 pack a day smoker Currently, 54 days smoke free Vaping 36 mg e-juice (30 ml / week) It should be noted that I am not a doctor (but I am a scientist-geochemist). It is well known that cigarettes have a negative effect on the bodys circulatory system and that nicotine, by itself, constricts the blood vessels. Here is my story. About four years ago, I got a relatively extreme case of frostbite on three of my toes. The tips of my three toes are permanently black/purple and completely numb. In addition, one of them frequently fills with fluid which indicates poor circulation. It should be noted that when the toe fills with fluid it throbs and is quite painful. Since I quit smoking by using my e-cig exclusively, my toe has not filled with fluid or hurt. Over the first few weeks of being smoke free I hoped that my circulation was improving because my toes felt better; however, they did not look better. At this time, I was not sure if this was a coincidence or evidence that my circulation was improving. Over the last week (54 days smoke free), I have been observing changes with my toes. The back/purple portions are decreasing dramatically and I am starting to get a bit of feeling back in them. I am ecstatic, not only because my toes are getting better after all these years, but also due to the fact that, yes, nicotine may not be great for your circulatory system but appears to be significantly less harmful then smoking. I always knew that smoking and nicotine had a negative effect on the bodys circulatory system but did not know the relative effects of the two. In conclusion, nicotine may have a negative effect on the circulatory system, but it is extremely less dramatic when compared to the effects cigarette smoke.