Marcus Munafo, a researcher on the influences of addictive behaviour at the University of Bristol, UK, suspects that part of the problem is down to the other chemicals present in real cigarettes. Although nicotine is the primary addictive component of tobacco, there are other components in the smoke that enhance nicotine's addictive potential. The brain mechanisms behind this are unclear but animal studies suggest that chemicals in smoke other than nicotine inhibit up to 40 per cent of the activity of an enzyme called monoamine oxidase. Nicotine prompts the release of the neurotransmitter dopamine, whose action in the brain is linked to the pleasurable effects of smoking. It has been suggested that MOA inhibition might decrease the re-uptake of dopamine, giving genuine cigarettes a double-whammy effect.
I knew those extra chemicals played a big role in it all. I almost feel like the withdrawl from those is worse than the withdrawl from Nicotine alone.
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