I don't know how long you've been vaping and/or using cartos, but the same criteria applies for cartos in a tank as for cartos "on their own." If you're used to using cartos and have a way to decide when to change to a new one then go with that.
If you're new enough to cartos in general that you don't have a criteria yet, I've seen flavour drop-off listed by a lot of people--drop-off in flavour, vapour production, harder to draw through, &c. Basically, imo, it's just "once it doesn't work as well as a new one."
If the flavour is just "not quite right" but there's been no other changes, then it may just be the juice (or your taste buds) changing. On the other hand, a month seems to be about the average I've seen of people changing their tank cartos so it well could be time. Only thing I can think to suggest is to try a new carto--if the flavour goes back to normal then throw this one away and if the flavour tastes the same in the new one then just give this one a hot rinse (or quick boil) and save it to go back to later...