Well, I don't understand the science.. I would advise against comparing cigarettes to vaping on a dosage level. Because they only really match-up on paper.. In real life, based on the nic level of cig vs juice, I have gleaned. I am spend less than 1/2 the money I was on smokes, but also using 25%-40 more nic,by volume. That does not mean I am getting a higher dosage,I know. I do know I started with 20mg/ml nic in June of 2014, Now March 2015 I'm using 10-12mg/ml nic juice. I have reduced the amount of nic I use a day, in the vape by almost 50%. , FWIW I still vape today at the same power levels as when I started. So my nic level have been reduced due to NEED rather than to accomidate, high power levels.