People who report severe side effects from Chantix are often told that it's just withdrawal from nicotine, or the loss of their "lifelong friend," or something, not the drug. Well, we know that for some people it is the drug. People are so different in the way their bodies react it's rather pointless to speculate about what might be causing someone's symptoms. A process of eliminating possible causes is the only logical way to get a fix on what might be causing a particular side effect. In other words, if you're reacting differently than most people, you may have to experiment on yourself to figure out why.
One thing to think about is the research that shows smokers getting very different amounts of nicotine from the same number of cigarettes, because of differences in the way they smoke. That's the first thing I would look at, if I was noticing an increase in anxiety or a decrease in energy. But again, while pg may be perfectly innocuous in 99% of us, it's unlikely that it has no effect on some subset of users.
Some months after I started vaping when I began to develop dry eye, my immediate reaction was to blame it on the pg, although I know it's an age-related condition. But when I went to buy eye drops the ingredient list read: Propylene glycol, glycerine.
Ah, the old " A happened, then B happened, therefore A must have caused B" fallacy once again.