Hello JR789 and welcome to ECF.
Some people do experience irritation from certain flavors. Absolutely yes with throat irritation for example.
That is very dependent on how much flavoring is used in any given juice. It is also subject to the specific ingredients a flavoring company uses in creating a flavor.
I was never much for commercial juices. For me, all were seriously over flavored and way too sweet. Tried many.
Almost immediately after I started vaping I got into DIY. With DIY I am able to control, and tailor, my vaping experience to meet my desires.
The flavors we use in DIY are not created equally. The flavors we use in DIY are the same ones used in commercial juices. One company's pineapple may be very harsh while another company's is not. Same with peach flavors for example. There are flavors from every company that 'some' will feel are harsh or irritating.
As
@zoiDman posted, some people have problems with PG. You might be one of those people. Finding high VG, or 100% VG, juices might help you.