I used my (24mg) e-liquid once with a pre-made coil (.4 ohm, I ordinarily use a coil with between 1.5 - 2 ohms resistance..) that came with a RTA I got recently. I had made that particular batch of liquid with a flavor or two so the nic level was down to 21 or 22 mg, but still..

I did taste more of the flavor and got more of a 'nic effect'; but too much flavor and thankfully I didn't get 'nic sick'.