Sending a reply or even acknowledging them only cause more to magically appear in your inbox. Actually it's not magic as most spam these days is sent by bots and any sort of reply just tells them that have a valid email address. The unsubscribe feature in the microscopic fine print at the bottom is supposed to work by law but, as they say, good luck with that.
One of the emails although they probably all do it, when you delete them they just go away not even in the trash.