Vegetable Glycerin studies
Glycerol is one of the most benign organic liquids known to man. It is hype-allergenic, non-carcinigeic, non teratogenic and non-mutagenic. It is metabolized quite easily by a process called beta-oxidation. This process results in the production of CO2 and H2O and is a quite normal, common, and natural catabolic process.
The following is a few excerpts from a study called SIDS initial assessment profile of Glycerol Citation
Glycerol is of low toxicity when injested, inhaled, or in contact with skin
The NOACE for local irritant effects to the upper respiratory tract is 165 mg/m3
Glycerol is of a low order of acute oral and dermal toxicity with LD50 values in excess of 4000 mg/kw bw.
Glycerol has low potential to irritate the skin and the eye
Glycerol is not a skin sensitiser
Glycerol does not induce gene mutations in bacterial strains, chromosomal effects in mammalian cells or primary
dna damage in vitro
Overall, glycerol is not considered to possess genotoxic potential
No effects on fertility and reproductive performance were observed
No further work is indicated by this study, because of the low hazard potential of this substance.
FROM ANOTHER STUDY regarding PG
Studies have been done in hospital wards using PG in an air-sterilization application. In these
studies, humans were exposed to saturated and super saturated atmospheres for prolonged
periods without adverse effects.12 In 1971, the uptake of PG mist by humans was studied using
a 10% solution in labeled deionized water which was nebulized into a mist tent. Less then 5%
of the mist entered the body, and of this 5%, 90% lodged in the nasopharynx and rapidly disappeared
into the stomach. Very little PG was found in the lungs. 12
Robertson and coworkers (1947) exposed monkeys and rats to atmospheres saturated with PG
vapor and found no adverse effects in animals after periods of 12 to 18 months.30 Rats exposed
to a 90-day inhalation study using PG aerosol at concentrations up to 2,200 mg/m3 (160, 1000
and 2200 mg/m3), for 6 hours/day, 5 days/week did not demonstrate systemic toxicity. However,
it was reported that there was a significant increase in the number of goblet cells (a type of
secretory cell found in the top layer of the intestinal and respiratory tract that secretes mucus)
and/or an increase in the mucin content of the existing goblet cells in the nasal passages of rats
exposed to the high and medium doses. In addition, the PG concentration in this study caused
nasal hemorrhage and ocular discharge in a high proportion of animals, all of these reversible
effects are considered to be the result of dehydration of the nares and eyes.23 The dehydration
would be expected with PG, as it is a hydroscopic material and can cause irritation simply by
removing excess water from the eyes and nasal passages.
Minute changes in cilia cell structures were observed after rabbits had been exposed to 10%
PG for 20 minutes by inhalation. It was reported that the goblet cells were discharging mucous
or were completely exhausted.