It's not necessary. But the other flavor will be there for a while. If you want the new flavor to be purely the new flavor, it's a good idea to change out the carto.
I don't use cartos that much anymore but when I did, I would designate one for menthols, one for coffees, one for fruit, etc. Most people have more than one tank going at a time.
I use 808, and im not sure if they're the same, but I'm sure you will get some help. I rinsed mine in hot water and the sprayer thingy on the sink, then let them dry out for a few days and used them again.
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