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So - are we getting it or are we not - nicotine

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So one can get about 10 days of clean WTA from 1 days' nasty smokes. That's why I tried extractions myself in a primtive manner - it's a great ratio :)

"and we don't vape ourselves silly trying to get something that for some of us, no amount of nicotine alone can provide" - pizza with a topping :)

btw : NAS is 'Natural American Spirit' cig brand - said (is?) to be a more unadulterated tobacco cig.

ps : not tried the pure WTA myself as yet, but suspect it might be even better in satiation creation that smokes (i think it quite likely that WTA is more MAOI rich than smoke).
 
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hittman

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    Yes Kurt, that was a great review. That is exactly what I thought when I tried it the first time. It is unlike any other liquid out there and believe me I ran thru more than my fair share of liquid samples before finally finding snus. For me if I vaped too much of the WTA then I would almost feel guilty like I had been smoking. I am glad that others are getting a chance to sample the WTA. It puts vaping in a whole other light. I am at the point now though where I enjoy snus but would definitely buy WTA liquid if it was available for the times when I do want to vape.
     

    Kurt

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    BCB: dreamy is definitely the word. It is not really like a nic rush...much warmer and almost intoxicating. Even at 12 mg, the effect of tingly/relaxed forehead is strong. Never got that from a juice before. Only get that from a cigar or several smokes. Of course its a bit hard to mentally remove the CO effect, which is certainly dominant when smoking. But this tells me that there is far more to smoking than CO and nic. Snus does not do the forehead thing to me at all, although it does shut down cig cravings. In fact, this forehead feeling I get is almost the same as eating very hot peppers...feels almost on the verge of sweating above the brow.

    One thing I am finding is I cannot vape this continually, even as 12 mg. I have zero issues with chain-vaping 18 mg all day long, but this WTA fills you up fast! I think I will make a 6 mg juice from it and see how that does...tomorrow...hehe.

    Kin: I think you may be right about the relative amount of MAOIs in WTA vape compared to smoke. Of course, only GC-MS will tell us what is really in it, and then we would have to do the same with tobacco smoke (not tobacco itself), but the physiological effect I feel is profound.

    Outside of smoking way too many cigs in a short time, which would include lots of CO poisoning effects too, if you have ever had Gauloise rolling tobacco, which is very strong and heady, or inhaled a cigar or strong pipe tobacco for a while, that is what I feel.

    Hitt: I find it interesting that WTA and snus each kill cig cravings for me far better than all-nic juice. And yet the feeling I get from those two are totally different. I do not feel like I've smoked with snus, and yet the craving is gone and I do feel "full" or "satiated". WTA is definitely like I've smoked strong tobacco, as I state above. And yet the theory was we are getting a similar balance of alks with snus and WTA.

    I love it when the more you experience and learn, the less you find out you know. :)

    TV: I am wondering if the pipe tobacco would have lead to the same WTA juice if DVap had used his current method. I know that what he does now removes much of the coloration compounds first, and then the WTAs in a subesquent step. That said, I am also wondering what else in pipe tobacco, which is about as processed, fermented, adulterated as tobacco gets, comes along for the ride, like nitrosamines and other junk.

    Anyone know if NAS is fermented? And if so, DVap, will any nitrosamines, which are produced in fermentation, get "flipped out" with acid or base? I PMed you with similar thoughts, so sorry for the repeat.
     
    "I find it interesting that WTA and snus each kill cig cravings for me far better than all-nic juice. And yet the feeling I get from those two are totally different. I do not feel like I've smoked with snus, and yet the craving is gone and I do feel "full" or "satiated". WTA is definitely like I've smoked strong tobacco, as I state above. And yet the theory was we are getting a similar balance of alks with snus and WTA."

    Some initial thoughts. First of all, the tobacco type is different but the major factors are probably the rate of alkaloids entering the bloodstream (somewhat slower with snus) and, perhaps most significantly, that with snus certain alkaloids would be preferentially disolved / released as the mouth is essentially a slightly alkaline water based solvent, plus some enzymes. In short, snus offers a subset* of the alkaloids in WTA.

    ~~~

    On the hypothesis that WTA is more MAOI rich - I am thinking that the nicotine is more robust and preferentially survives the combustion / is more volatile / less readily oxidised. The idea is also based on the observation that analogs are only partially satiating (satiate for a quite short period). From BT's standpoint this is ideal for maximum sales volumes - something that gives pleasure but not for very long so another is needed soon after. One might wonder if that is just good luck on their part or some tweaking has been going on. Additional thought : because the nic is somewhat antagonistic in effect to the MAOIs, smoking analogs in quick succession cannot achieve the desired satiation; WTA seems to have a better ratio of nic to other alkaloids for satiation / calming.

    ~~~

    * later : Maybe overstated - they might be quite similar, with nearly all alkaloids present and in similar ratios; but still, not quite the same.
     
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    From Wikipedia, a brief recap on tobacco specific nitrosamines :

    "These nitrosamine carcinogens are formed from nicotine and related compounds by a nitrosation reaction that occurs during the curing and processing of tobacco. They are called tobacco-specific nitrosamines because they are found only in tobacco products (and possibly in some other nicotine-containing products) [being formed from nicotine]. Thus the tobacco-specific nitrosamines are present in both "smokeless" tobacco products such as dipping tobacco and in cigarette smoke. They are present to a significantly less degree in snus, a Swedish style snuff that is not fermented and is pasteurized. They have been detected in American style "smokeless" tobacco products, but Health New Zealand concluded, in their study, that carcinogens and toxicants were present only below harmful levels. They are among the most important carcinogens in cigarette smoke, along with combustion products and other carcinogens."

    Zeolite adsorption can reduce nitrosamine levels but how suitable / necessary something like this would be wrt WTA production I'll leave to the chemists.

    As an aside, as nitrosamines can be formed from nitrites in the highly acidic environment of the stomach, it is a good iidea to avoid foods where nitrites are used as a preservative (preserved meats).

    ~~~

    Fermentation of tobacco is done to improve taste and burning, but also reduces nic content and raises nitrosamine levels (partly by conversion; and presumably reduces/alters other alkaloids too).
     
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    Kurt - re forehead effect : this article might be of interest.

    "These data show that smoking causes an acute increase in relative blood flow in forehead skin in light smokers compared to heavy smokers, suggesting a potential induction of tolerance in regular users of tobacco."
     

    Kurt

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    From Wikipedia, a brief recap on tobacco specific nitrosamines :

    "These nitrosamine carcinogens are formed from nicotine and related compounds by a nitrosation reaction that occurs during the curing and processing of tobacco. They are called tobacco-specific nitrosamines because they are found only in tobacco products (and possibly in some other nicotine-containing products) [being formed from nicotine]. Thus the tobacco-specific nitrosamines are present in both "smokeless" tobacco products such as dipping tobacco and in cigarette smoke. They are present to a significantly less degree in snus, a Swedish style snuff that is not fermented and is pasteurized. They have been detected in American style "smokeless" tobacco products, but Health New Zealand concluded, in their study, that carcinogens and toxicants were present only below harmful levels. They are among the most important carcinogens in cigarette smoke, along with combustion products and other carcinogens."

    Zeolite adsorption can reduce nitrosamine levels but how suitable / necessary something like this would be wrt WTA production I'll leave to the chemists.

    As an aside, as nitrosamines can be formed from nitrites in the highly acidic environment of the stomach, it is a good iidea to avoid foods where nitrites are used as a preservative (preserved meats).

    ~~~

    Fermentation of tobacco is done to improve taste and burning, but also reduces nic content and raises nitrosamine levels (partly by conversion; and presumably reduces/alters other alkaloids too).

    Exactly, kin. Which is why I am wondering what the chemical outcome is of them in a typical extraction with acid and base washes, and this very clever ionic solid filtration? They are initially quite present in US tobacco, but not so much in swedish snus. And a can or two of good relatively unflavored snus is much cheaper than the same amount of Am Spirit tobacco. And probably able to "give up the goods" better too, since it is designed to be released by saliva.

    As for the forehead effect (thanks for finding this article!), I guess with a lot of time and WTA vapage, it might lessen or go away altogether, based on the article. I personally like the physiological effects, if for no other reason than it gives an indicator that its working or one has had enough.

    As for the time issue you brought up earlier, it has always been my belief that nic has a very short half-life in the bloodstream, and is introduced to the bloodstream the fastest by way of the lungs, so fast spike up and relatively fast decay down. Vaping is primarily absorbed orally and in the throat, so is a slower absorption. Same half-life in the blood, but the nic is more trickled in over a longer time, so the blood levels remain more constant over time, and taper off slower, since the nic is often still being absorbed. That's how I think about it anyway.

    As for the difference between snus WTA release and the WTA juice, I don't know. And I don't think we will really know until someone, somewhere gets mass spectra of the saliva/vapor. I need to pay attention to the forehead effect the next time I use snus... perhaps later today. I generally get a nic blast initially with snus, and have to drink water to get rid of the niccups, depending on the snus, but it is a common effect with me. But I don't recall the forehead effect. So what is it??? It can't be nic, as it is only 12 mg, and that would never do much at all with me.

    Deliciously mysterious, this stuff. We think we know, which is why DVap made it in the first place, but there are contradictions here that are very puzzling...but getting us even farther along than we were before. Love it.
     
    My guess is that it is the nic - as i understand it, the nic cause vaso-constriction in certain places that cause an increased blood flow in others, notably the forehead, but that in more hardened nic users there is a tolerance.

    A poosibilty of histamine release perhaps, akin to a niacin flash ?
     
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    DVap

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    I would be very hesitant to try too hard to compare flavor characteristics between the current WTA and the "ashtray" WTA that makes Vic get all misty when he recalls it (much of the ashtray -vs- clean might be related to me getting "better at it").

    I've thought about the advantages of using snus or even Stonewalls as a starting material due to their being lower in TSNA's than regular tobacco. The health analysis is easy, but I've not done the cost analysis... so here goes. 150 grams of NAS runs about $28 and can produce perhaps 60 mL of 30 mg WTA. (This ignores for now the significantly greater cost of other extraction materials). If I got 10 tins of Thunder Extra Stark, that would run me maybe the same $28 as the NAS. Just using the nicotine content to estimate the alkaloids, we have 16 mg x 24/tin x 10 tins = 3.84 grams. Allowing for 30% loss during the extraction, that gives around 2.7 grams of alkaloids, or 90 mL of 30 mg low TSNA WTA.

    Lower TSNA's and comparable or better material cost... works for me.
     
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    exogenesis

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    I'm looking at that calculation & thinking : where'd all the extra alkaloids come from in the Thunder ,
    thought NAS was pretty much the strongest (& cleanest - for smoking) baccy,
    so if the Thunder has about twice (per dry gram),
    then it comes from 'fortification' with --- nicotine ?, or snusjuice ? ---
    which <might> make the other WTA components from 120 dry grams of Thunder come up short
    (in relation to the nicotine), c.f. the 150 dry grams of NAS ??

    Hope that was in an earth-language...
     

    Kurt

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    DVap, that is good news! The TSNAs might be a moot point...they may well be soluble in the extraction solvent, but what are their pKb's, on average? It might be they never get into the flips in the first place. I tried googling this, but it seems every time nitrosamines are brought up, rather than giving important info, the author has to side track the discussion to cancer, rather than chemical properties. Probably to give validity of the study to those that payed for it.

    And I wonder about the use of sterk snus. I mean, there is no shortage of nic around, and an OP might give a more "natural" alk balance. To me its not the amount of alkaloids you get, its what they are. One can always boost the nic later with any unflavored juice.

    Again today I am vaping mostly 12 mg wta. Had two snus OPs (General Mint and Roda). With two snus portion and nic-only vaping, I would still have a some key times during the day when I would have a smoke. Those times came and went before I realized they had, several times...in fact I just realized it now at 8:30 PM.

    And thus my signature...
     

    Kurt

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    I'm looking at that calculation & thinking : where'd all the extra alkaloids come from in the Thunder ,
    thought NAS was pretty much the strongest (& cleanest - for smoking) baccy,
    so if the Thunder has about twice (per dry gram),
    then it comes from 'fortification' with --- nicotine ?, or snusjuice ? ---
    which <might> make the other WTA components from 120 dry grams of Thunder come up short
    (in relation to the nicotine), c.f. the 150 dry grams of NAS ??

    Hope that was in an earth-language...

    exo, it seems that extra-sterk would be fortified, as I don't think they use a special tobacco for that. nic only, not the other alkaloids. that's just my opinion though. in fact they all may be standardized, as they are all about 1 g of tobacco in a normal sized portion.
     

    DVap

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    16 mg/g is only 1.6% w/w, so I don't really believe it would take any sort of nicotine fortification to accomplish that.

    The more relevant question might be, "How well does one of those 16 mg portions scratch the itch?". If the answer is, "quite nicely", then that 16 mg portion probably represents an efficacious starting material.
     

    BCB

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    Kurt, did you notice a stronger "forehead" response when you were vaping 30mg than when you'd cut it down to 12mg? Also, now that you spent a whole day vaping 12mg, did you notice that wonderful, calm, aahhhhh feeling had lessened from when you were vaping the 30mg strength? Or are you having that dreamy feeling just fine at the 12mg level?

    I'm questioning the notion that the "forehead" thing is just nicotine if it's dampened by extended use. You've been using nicotine for years, right? I've got a feeling the "forehead" thing has additional causes and I'm thinking it's other stuff--maybe part of the calming effect of MAOI's. Like joy/calm or something. These thoughts are not based on any hard science at all--just based on watching my body's response to various drugs over my lifetime. When you described that forehead feeling it made me think of the feeling of Quaaludes. I have no idea what used to be in them, but it triggered some memory from my youth.

    PS: I believe that people who need the WTA liquid would be willing to pay the higher price. I know I would. I would get a third job to pay for it if I had to.
     
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    brokenbrains

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    DVap, that is good news! The TSNAs might be a moot point...they may well be soluble in the extraction solvent, but what are their pKb's, on average? It might be they never get into the flips in the first place. I tried googling this, but it seems every time nitrosamines are brought up, rather than giving important info, the author has to side track the discussion to cancer, rather than chemical properties. Probably to give validity of the study to those that payed for it.


    My notes say pKb = 8.84 for NNN. That's about all I got for pKb's.

    Here's some partition coefficients (logP, o/w):
    NNN: -.076
    NNK: .090
    Cotinine: .040
    Nornicotine: .50
    Anatabine: .93
    Nicotine: .93
    Anabasine: .96

    Seems to indicate that in liquid-liquid extraction, you're probably going to lose a lot of NNN and some NNK (relative to alkaloids you'll keep) when moving into non-polar solvent.
     

    TWISTED VICTOR

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    Oh, who was that ?;)

    Don't you hear them, too :confused:??

    I'm looking at that calculation & thinking : where'd all the extra alkaloids come from in the Thunder ,
    thought NAS was pretty much the strongest (& cleanest - for smoking) baccy,
    so if the Thunder has about twice (per dry gram),
    then it comes from 'fortification' with --- nicotine ?, or snusjuice ? ---
    which <might> make the other WTA components from 120 dry grams of Thunder come up short
    (in relation to the nicotine), c.f. the 150 dry grams of NAS ??

    Unless possibly in the case of Thunder SnusX (which still isn't yet available). The average 1 gram portion is about 50% H2O, whereas the es (16mg/g) SnusX should weigh-it at 1 gram dry, plus the buckets should be (whenever V2 stops dragging their heels) priced below regular per portion prices. Just wanted to throw that in since they promise it's just around the corner. And promise and promise and promise......


    Hope that was in an earth-language...

    Next time I visit I'll ask around :p.


    The more relevant question might be, "How well does one of those 16 mg portions scratch the itch?". If the answer is, "quite nicely", then that 16 mg portion probably represents an efficacious starting material.

    Quite nicely. I can vape 36 and 48mg liquid along with a 8mg snus and not feel like I'm there yet, even though after a while I can't take any more nic. A 16mg portion has a nice mellowing effect that tames all skin-crawl. Then there's the case of Vaporer, who generally seems happy with low nic liquids, but uses Thunder all day. I think the higher nic in es snus carries its equal share of the other alkaloids, too. For God's sake, look at me. I'm not divorced nor are there any warrants for my arrest...........:).
     
    My notes say pKb = 8.84 for NNN. That's about all I got for pKb's.

    Here's some partition coefficients (logP, o/w):
    NNN: -.076
    NNK: .090
    Cotinine: .040
    Nornicotine: .50
    Anatabine: .93
    Nicotine: .93
    Anabasine: .96

    Seems to indicate that in liquid-liquid extraction, you're probably going to lose a lot of NNN and some NNK (relative to alkaloids you'll keep) when moving into non-polar solvent.

    Good news :)
     
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