it should. my wife and i switch off between leaded and unleaded
ejuice and dont notice a differece between the unleaded. then again, she is more of a smoking addict than a nicotine addict. i am the same way. there are times though, when the nicotine is NEEDED, ya know?
you can always try it yourself and whip yourself up a batch of the unleaded. just go to a hobby store or a cake shop and get a little bottle of glycerin and a small bottle of your favorite flavoring. mix em up together and then try it out. then let us know how it was!