Hmmmm?
Well first, the Subox is a VW device. Your battery is powering the chip, which (according to what you set it to) will output the given voltage/wattage. Assuming it wasn't designed by a donkey, the chip should be smart enough to not let you set the wattage to something that would exceed the amp limit of your battery. (And I'd hope that's the case, because I have one in the mail too).
Secondly, when you take an 18650 battery off the charger the voltage should be 4.2V. As the battery is drained, the voltage will decrease. In something like a mech mod, you cannot adjust the voltage. The voltage is simply the amount of volts left remaining in your battery. For a regulated mod (ie: the Subox mini) the chip is converting the voltage from the battery (magic) to your desired voltage/wattage.
Thirdly, the Subox can go up to 50W max. At 50W (max wattage) you'd need a ~.13 ohm coil to actually max out your battery's amperage. So basically, as long as you're not throwing something with CRAZY low ohms (which I wouldn't recommend on any device, really) you'll never even come close to the amp limit of your 18650 batteries.
You can use the
Ohm's Law calculator at Steam-Engine to plug in some numbers and figure out what wattages produce what amperages/voltages given what resistances/etc..
Short version:
With the Subtank and a .5 ohm head, you will be able to crank it up to 50W. No worries, no problemos, it'll be 100% kosher.