Anatabine - key player ?

kinabaloo;4727535 said:
I would be interested to know if the simple combination of nicotine and anatabine*, in appropriate ratio, would be as effective as WTA (possibly even beter). The obvious omission being the more minor harmala alkaloids that have some reasons to be thought possibly important. On the other hand, one could avoid nornicotine.

To my mind this combination would still be a tobacco extract, little more complex that just nic. 50/50 if it would be as effective (or more accurately, as effective for as many people) as WTA. If I had to choose, I'd bet on this simle dual combination as indeed being effective.

Ultimately WTA might be a steping stone to something better. Yet a very important one nonetheless.

If I was Ethan, or otherwise in a position to do so, I'd do some small trials.

* A MAOI; and perhaps as much as 4% of smoking tobaccos; so not that minor!

+++

ps: oftentimes nicotine and smoking are used interchangeably (!). It is looking increasingly to be the case that benefits attributed to nicotine are more accurately associated with anatabine.

Comments

I agree anatabine is major. Nornicotine also has some maoi properties. I beleive the mao inhibition enhances the beta endoprhin effects of nicotine like compounds, as it does with similar chemical actions - producing the wta effect. And the reason why tobacco itself is again different is harman mao's are primarily mao a, not mao b like these native maos (+ sedative terpenes like linalool in tobacco -which some like joytech add to their liquids). Even carbon monoxide may play a role in tobacco combustion effects.
 

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