Beta Carboline MAOIs - towards a more effective e-liquid

tceight;1844493 said:

20g of tobacco, finely ground and packed down with the oil takes up 45ml of space.
One thing I was thinking of to 'speed up' the process a bit, was to use a narrower tube. 1/2 or even 3/8 of an inch. This would allow the oil to have a higher head pressure and more force.

The temptation will be to try to get 'as much as possible' from the tobacco by using a lot of oil.
This will work against you later though, when trying to extract it.

I've been punching some numbers to figure out why it worked, when the materials we are using are so inefficient, and one of the keys is to have a minimal volume of highly concentrated oil to begin with. I'd like to do another extraction 1ml at a time to see if there is a sudden colour change, and thereby have an idea of when the majority is extracted. I aimed for about 1ml per gram of tobacco as a starting point, and the extract after that was yellower rather than amber.

why a small volume?
because our second transfer into the glycerin is inefficient at the pH levels we are using.

assume for easy numbers we are getting only 1/2 volume for volume.(should be better than this)

so if there is 1000mg in 50ml, and we transfer to 50ml of glycerine,(all at once) there would be 500mg transferred, or 10mg/ml

if there is 1000mg in 100 ml, and we transfer to 50ml then we only get 330mg. or 6.6mg/ml


even doing a series of sequential extractions like I did the first time, it doesn't help a whole lot.
I ran some spreadsheet examples,
assuming equal affinity of alkaloids (worst case)
1000mg in 40ml of oil and extract into 40ml of pg, 500mg transferred
1000mg in 40ml of oil and extract 10ml 4 times 590mg transferred
1000mg in 40ml of oil and extract 5ml 8 times 610mg transferred

There are lots of ways to increase the efficiency of transfer, but they become tedious.
The best way is most likely to decrease the pH well below what cream of tartar can do, but we want to keep it vape safe, and this 'works' if inefficient.

One other thing, the wash step. I think I lost a lot more in that step than I needed to, so use 1/10 the volume I posted, or skip it entirely and the emulsions will clean it up for you.

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