Thinking about the relative nature of smoke and vapor. Smoke will contain other alkaloids beside nicotine, but what nicotine is released is more likely to be oxidised than the nicotine in vapor (because largely the 'vapor' is mostly actually a mist of tiny droplets of PG/VG with the nicotine less susceptible to oxidation as it is mostly dissolved in the PG/VG carrier; there will still be some oxidation given the small droplet size (large surface to air ratio). Some 25-35% of the nicotine in vaping will be oxidised (best guess) before it enters the blood stream whereas in smoke it is probably a lot higher (say 60-70%, best guess, maybe more).
So, nicotine may be less important than generally thought (other than as a precursor).
And 'steeping' creates a 'vapor' that is more like smoke in alkaloid profile (primarily, less nicotine, more cotinine; at the point of absorption into the bloodstream).
So, nicotine may be less important than generally thought (other than as a precursor).
And 'steeping' creates a 'vapor' that is more like smoke in alkaloid profile (primarily, less nicotine, more cotinine; at the point of absorption into the bloodstream).
