"In the other report, a crossover trial of 40 ENDS-naïve participants, smokers were assigned on different days to use an ENDS with a 16 mg or a 0 mg nicotine cartridge, a nicotine inhaler, or their usual brand of cigarette.7 In a PK study involving a subgroup of nine participants, the 16 mg ENDS yielded a maximum nicotine concentration in blood plasma of 1.3 ng/ml, the inhaler 2.1 ng/ml and the tobacco cigarette 13.4 ng/ml. Importantly, the 16 mg ENDS, 0 mg ENDS and nicotine inhaler all significantly decreased desire to smoke. The tobacco cigarette produced the greatest decreases in desire to smoke. The 16 mg ENDS was rated as more pleasant than either the 0 mg ENDS or the inhaler."
Electronic nicotine delivery systems: a research agenda
Electronic nicotine delivery systems: a research agenda
